Chapter 292: Doing something big (first update, please subscribe)

In fact, at this time, Zhou Cheng can argue with Luo Yuncheng and be a little more high-profile. Isn't it what you told him to do? You should be honest and decisive?

But Zhou Cheng's purpose today is not simply to show off, but has many other intentions.

Therefore, Zhou Cheng explained the relevant theories in detail, omitting some anatomical knowledge that had not been published yet, and explained them one by one.

This explanation is based on the basics, goes beyond the basics, explains it in simple terms, does not contain any nonsense, but is very profound.

Pure academics don't actually mean much. On the contrary, whether you are listening or thinking, you need to pay full attention.

It doesn't sound simple, but it's even more complicated to operate.

Fortunately, Luo Yun and others are good students with excellent research qualities, so even though they had many doubts during the listening process, they did not interrupt Zhou Cheng's explanation immediately.

As soon as Zhou Cheng finished speaking, Chu Hanbo's question came, and he said sternly: "Zhou Cheng, even if you successfully blocked the entry and exit of the soft tissue vascular pedicle of the osteosarcoma in the middle tibia!"

"But you should also know that your current operation is not universal and generalizable."

"Operations that are not repeatable and generalizable are not of much value. Applying what you have learned is the right way. How do you solve this problem?"

Chu Hanbo raised this question very well. He assumed that all Zhou Cheng's operations were correct and could meet expectations to a certain extent. However, there was a very critical issue.

Can other people do this kind of operation?

For now, with such a high level of difficulty, it is theoretically very difficult for ordinary people to clarify the relationship.

The more subtle and minute the operation, the more difficult it is. A little carelessness may lead to uncontrollable accidents!

Moreover, the efficacy of this surgery cannot be evaluated yet.

Chu Hanbo was not unconvinced. He was really thinking and looking for a solution to the problem. Zhou Cheng said: "Indeed, Senior Brother Chu's consideration is very reasonable, and it is also one of the biggest obstacles at present."

"However, compared with facing the uncontrollability of tumors, as long as we solve such a relatively objective problem, I think it is relatively simple."

Zhou Cheng continued: "Brother Chu, can I not answer this question of operability and reproducibility? Let me talk about the follow-up treatment ideas. Let's first think about the treatment ideas for solving the tumor, and then clarify the operation.

Promotional issue, right?”

Zhou Cheng's words seemed to be asking, but in fact he was making a decision in a dominant position.

Although there are many problems, if you have to sort them out one by one and jump here and there, it will only make people's thinking more confusing.

When there are many things to do, dividing the problems into levels and steps is a very scientific and effective way.

Chu Hanbo expressed his approval, nodded and said: "I am too anxious. Please ignore my question just now. Zhou Cheng, you continue."

Zhou Cheng nodded and continued: "My summary ideas must have been reviewed by several teachers."

"Blocking the blood source and outlet of the tumor is actually only the first step. This can ensure the nutritional source of the tumor cells."

"But in fact, we all know that the composition of tumors is divided into range components and individual components."

"The scope component is the tumor tissue. This part of the tissue has rich vascular circulation, which is the most basic source of energy for osteosarcoma cells."

"But for individuals, osteosarcoma, including any tumor, exists in the form of cells and is actually spread!"

"The shedding of tumor cells, their entry into blood vessels, and their invasion are an important reason for tumor growth, spread, and distant metastasis. Teachers, do you think this statement makes sense?"

Zhou Cheng didn't say a word, let alone say it to death.

There are some things that he knows that others may not know, but the train of thought and the corresponding train of thought are drawn out. With the attainments of Chu Hanbo and others, it is unlikely that they will not be incomprehensible.

Luo Yun nodded first: "There is such speculation at present, you continue."

Zhou Cheng organized his words a little and said: "The remaining blood vessel network of the tumor does not rule out the possibility of undetectable collateral circulation from other capillary networks."

"This kind of capillaries cannot be detected even through inspection. Therefore, in this case, one additional operation we need to do is to remove the vascular network between the entrance and exit of the vascular network we just blocked.

, block it again to prevent the blood inside from flowing again."

"The obstructions at the entrance and exit that we just blocked just become two plugs. In this way, even if there are other undetectable blood circulation networks, blood circulation can be avoided."

When Luo Yun heard this, his eyes flashed slightly.

Zhou Cheng's backhand directly cut off all the back channels of the tumor's blood vessel network, basically completely blocking all blood circulation in the tumor's general tissue.

He had doubts before. Zhou Cheng only blocked the entrance and exit of the vascular pedicle, so how could he determine that there were only these two entrances and exits?

In fact, Zhou Cheng only blocked the entrances and exits of two relatively large aortic arteries. He also blocked all the nutrient blood vessels of the tumor!

As he spoke, Zhou Cheng continued to operate, turning the syringe in his hand slightly in another direction, and then said: "The diameter of our needle is only 0.18mm. In actual operations, we can use multiple blocking channels."

"But now, because we are not prepared enough, I will use this syringe again, return to the entrance area, cross the blocking point just entered, puncture and go deeper inside."

"There is not a lot of blood that can be penetrated with a diameter of 0.18mm. Moreover, once we block all the pathways inside the vascular network, this approach, even if it is fully opened, will not allow blood to flow again. We

It can be completely blocked at the more proximal end, segmented, or ignored."

As Zhou Cheng spoke, he inserted the syringe and needle into the posterior tibial artery as if he were back at home.

This operation is very psychedelic, but it looks very strong, without any hesitation, fast and accurate.

Although it cannot be copied, it looks really pleasing to the eye!

After Zhou Cheng finished the operation and injected a certain amount of blocker, he still did not pull out the syringe.

Instead, he said: "Teacher Luo, now, I have blocked almost all the tumor body and surrounding vascular network. The blood inside may not all be filled with blockers, but it doesn't hurt!"

"And I just said that tumors have two parts: scope and individuality. The source of nutrition that we can cut off through the vascular network can only be most of the tumor tissue. This step is taken from the treatment of bone tumors.

Complete excision and debridement.”

"However, there must be free tumor cells outside the vascular network and most of the tumor tissue."

"We not only blocked the vascular network of bone tumor cells, but also blocked the vascular network of surrounding normal tissues. Therefore, bone resorption will inevitably occur after surgery and the formation of lacunae will occur."

"According to our concept of debridement in orthopedics and trauma surgery, if there is a cavity left after trauma, the possibility of bacteria remaining is almost 90%, so we still have to find ways to seal the cavity."

"In trauma surgery, our method of closing the cavity is to fill it with bone grafting or copper sulfate, bone cement, etc. However, we cannot solve this kind of osteosarcoma surgery in a similar way."

"We can still replace traditional incisional surgery with bone grafting, but we can still have other methods, which is to inject bone formation factors later, or after bone resorption is discovered!"

"Although bone resorption has already occurred at this time, it must not be absorbed that fast. There is still a skeleton. If the bone cells can be refilled, it can still be restored to its original state. It just so happens that our bone repair ability is extremely strong, and almost as long as it is restored

With blood supply, a theoretical complete repair state can be achieved."

"The rearrangement of the concentrations of osteoclasts and osteoblasts will have the effect of reconstructing bone tissue!" Zhou Cheng analyzed it one by one and cited side effects.

Whether it is traditional tumor treatment or trauma surgery knowledge, it can be used, and there are no laymen present. Therefore, although this paragraph sounds long, in fact, everyone can understand it very quickly!

Han Xiaoming sighed and said: "Xiao Zhou's clinical experience is actually better than ours. We just wander around in the laboratory. We really have never thought that after tumor cells and normal bone cells shrink, die and crack, what remains

The question of whether the skeleton can be reused.”

"This is indeed a very genius and novel idea, and its operability is much higher than the previous method of blocking blood vessels."

Fang Fang also understood what he heard. However, he glanced at everyone and found that no one continued to ask questions, so he slowly said: "Brother Cheng, you just said that tumors are divided into range and individual. What you are targeting now is

Just a wide range of tumor tissue, then scattered tumor cells?"

"How are you going to deal with it? Or rely on the traditional kind, chemotherapy?"

Zhou Cheng nodded: "The existing cancer treatment options have their uses, and they cannot be completely abandoned. However, if it is just to kill the remaining tumor cells after surgery, the amount of chemotherapy drugs required will not be too much.

"

"Of course, this is just one of the alternatives."

"There is another characteristic, which is to make good use of the survival characteristics of tumor cells. We should find that when fibroblasts form clusters, some fibroblasts will turn into nutrients for other fibroblasts."

"In other words, when there are a large number of fibroblasts that are dying or need a lot of energy, some of them will be sacrificed."

"Tumor cells also have such autophagic lysis characteristics. The reason why we choose to cut off the blood supply of tumor cells is also because of this."

"It can make most of the tumor cells kill part of their companions when they are dying, even if they cannot escape the fate of death in the end."

"Of course, appropriate auxiliary chemotherapy is still needed. However, at this time, the dosage of chemotherapy drugs can be reduced to the greatest extent."

"The above is the theory of treatment effectiveness!" Zhou Cheng slowly concluded, finishing the first point.

He had said these words to Mr. Zeng, Mr. Gui and others, but it was for a defense at that time and could not be put into practice. Therefore, it sounded far less powerful than seeing it with his own eyes. It was so shocking that it may not have convinced them anything.

After Zhou Cheng finished speaking, Han Xiaoming was the first to applaud.

"It's quite exciting. Zhou Cheng, you skipped the basic research stage and just used clinical thinking to find such a good treatment idea. You have put in a lot of effort!"

"Unexpectedly, through pure technology and without too much drug assistance, it is possible to achieve a certain degree of tumor elimination."

"With traditional tumor resection, scattered cells still have blood supply, and will lose the 'antagonism' and restriction of the bulk tumor, and will regenerate, relapse, and metastasize to distant places, giving off stronger vitality."

"So the current cancer treatment plan is to strictly implement a full course of chemotherapy before and after surgery, but even so, there are still some cancer patients with poor prognosis."

"And even if a cure is achieved that is currently considered clinically, the postoperative survival time and quality of life are still limited."

"Because of the success of the development and clinical application of targeted drugs for breast cancer, most of the current research directions for tumors are focused on finding specific targeted drugs."

"But actually, maybe..." Han Xiaoming didn't finish his words, but his words undoubtedly affirmed Zhou Cheng's thinking.

Then he turned to look at Chu Hanbo: "Senior Brother Chu, Senior Brother Luo, what do you think?"

Chu Hanbo and Luo Yun were both several years older than him. Even if Luo Yun was just studying for a Ph.D. now and Chu Hanbo was still studying for a Ph.D., he was just his younger brother.

The research team originally consisted of just the two of them. Luo Yunyuan was in Shashi and participated in discussions and plans remotely.
To be continued...