After talking about Wu Hongbo, Yang Rui's plan would be more smooth.

If you look down in the domestic biological world, there are too many people. You don’t know how many people you want in biology teachers in ordinary primary and secondary schools. However, when you enter the scientific research world, especially when you look up, there are very few people on the top of the pyramid.

Wu Hongbo started to come forward, and with such wonderful rewards as American travel, Huarui Laboratory quickly sent six invitation letters.

At the same time, Yang Rui continued to communicate with several pharmaceutical companies and actively communicated with Benjamin Law Firm.

The content he communicated was mainly a PCR lawsuit, and it was inevitable that the price negotiations for deferrosterone were involved.

Benjamin, who was named a partner of a well-known law firm, sued DuPont for Huarui Company, not only for the attorney fee of $2,000 per hour, but also for the purpose of taking on more business.

A landmark betting agreement, such a high-value contract, has always been a favorite thing for lawyers.

Milestone contracts are extremely complex, and the existence of betting agreements will cause people to be cheated if they are not careful. Pharmaceutical companies, like financial companies, are born evil and never trustworthy, and lawyers are naturally indispensable.

In a few days, almost all pharmaceutical companies accepted the landmark betting agreement model and then began a long detailed discussion. Some companies also had to consider whether to establish a joint venture subsidiary to undertake this work in accordance with Yang Rui's requirements.

In fact, the cost of developing new drugs is too high, and some medium-sized pharmaceutical companies are unable to bear it independently.

The average development cost of the first phase of clinical practice is US$1 million, and the milestone requirement is US$1 to US$55 million, which means that pharmaceutical companies may have to prepare a budget of more than US$56 million for this - although they cannot give Yang Rui as much as they want, they still have to prepare the budget to be qualified to compete.

The average development cost of phase II clinical development is US$20 million, and the milestone requirement is US$20 million to US$60 million, which means that pharmaceutical companies may have to prepare a budget of more than US$80 million for this.

The average development cost of Phase III clinical is US$100 million, and the milestone Yang Rui requested is US$30 million to US$90 million, which means that pharmaceutical companies may have to prepare $190 million for this.

As a milestone project, the maximum budget of the entire project may reach US$330 million, which is no longer cheap. It is even a sky-high price to pay back the money, which means cutting off one-third of the budget, and the final cost is still US$200 million.

This is actually just the average development cost of an ordinary drug.

Of course, the cost of a pharmaceutical company of US$200 million is a phased expenditure, which also means that Yang Rui's income will also be phased.

The easiest thing for him to get money is the first phase of clinical trials. As long as the safety clinical trial is passed, he will get at least 10 million US dollars or 20 million US dollars or 40 million US dollars or 50 million US dollars. As long as the contract is signed, the money will be almost certain to be obtained within half a year.

As for the delay of the second and third phases of clinical phases, it will take longer. If a pharmaceutical company decides to sell the ferroster directly after completing the first phase, it may take longer. And its income may not be more than the second phase. In fact, as far as Yang Rui knows, the money obtained in the second phase may be less than that in the first phase.

Because starting from the second phase, a large number of risks and costs actually gathered on pharmaceutical companies. Yang Rui's efforts made by the animal experiment were mainly fulfilled in the first phase of clinical trials.

According to the usual procedures of pharmaceutical companies, it often takes three or four years to complete the second phase of clinical practice. It is not surprising that it is slower, five or six years. If it is done quickly, it is rarely shortened to less than two years.

The third phase of clinical practice is far away. The development cost of US$100 million is mainly caused by a scale of 20,000 people. The average cost of US$5,000 per person is really not enough. These 20,000 people are not found casually by running around, but require doctors to approve or even introduce them, and sign complex contracts to be carried out in batches. The difficulty is even more difficult than selling a marketed drug. Only those largest marketing pharmaceutical companies can easily carry out such work. Pharmaceutical companies with a slightly smaller scale must be mobilized and make efforts to start a business again.

Yang Rui's eyes were mainly focused on the first phase of clinical stage. When all seven compounds of the first phase of clinical stage were passed, he could get the most part, and he might have luck of 40 to 50 million. As for the second phase and 3 phases, he would only get two to 30 million US dollars at most.

Of course, the final listing will also give him a generous bonus milestone, perhaps the scale of tens of millions of dollars will take longer, and maybe ten years may not be necessary.

"Time is really the most durable product." Yang Rui couldn't help but sigh at the progress table listed by Benjamin Law Firm.

"For you, in the future, just wait to count the money. Alas, if I had known that scientific research was so profitable, I would not have studied law school." Hong Kong lawyer Yue Ting gradually replaced Huarui's young lawyer who had no sense of existence before and officially became Huarui's company lawyer. He also knew about the relationship between Huarui and Yang Rui. At this time, he was even more moved when he looked at the documents sent by Benjamin Law Firm.

The one-hour charge of $600 is expensive, but it is still out of reach to earn $10 million.

Thinking about Yang Rui easily got the first ten million US dollars in his life, he was only in his early 20s and was still in a closed continent, Yue Ting was also full of emotion.

Yang Rui just smiled and said, "I care more about the money than counting money. You must prepare a contract with Jielikang as soon as possible and sell the Coenzyme Q10 catalyst first."

"OK."

“Have you booked a flight ticket to the United States?”

"PCR lawsuits are the first priority, and this must be handled well."

"No problem, Benjamin also attaches great importance to PCR. This lawsuit is well-known in the judicial and scientific research circles of the United States, and the business and Wall Street are also very concerned."

"Of course they care. Small companies are not good at making preparations for large consortiums, if I hadn't been fully prepared, I wouldn't know how to die." Yang Rui was also paying attention to the lawsuit in the United States at any time, but the more he paid attention, the more frightened he was.

The huge DuPont consortium is naturally not a problem to come and try to get a shot.

They actually have a chance to win. Yang Rui thought of this kind of thing incredible. I did PCR, but it was possible that DuPont could win.

However, this is American law.

DuPont used two Nobel Prize winners and a large amount of scientific research evidence to break out a way, proving that it has had relevant research since the 1970s.

Don't say, they really have it.

It was also Yang Rui who published an article before, conducted pre-research on heat-resistant polymerases, and also invited Nobel Prize winners, coupled with the joining of large patent law firms, which allowed Yang Rui to stabilize the situation.

Despite this, the debate between the two sides and the several trials lasted for more than half a year, which actually aroused considerable discussion in the industry.

Yang Rui had to add money to Benjamin Law Firm, which slowly increased the lawsuit budget to nearly $4 million.

For the Chinese, this is indeed an astronomical figure. Yang Rui has thought more than once in private that if he had not predicted the future of PCR, had accumulated enough funds and made sufficient preparations, this lawsuit would really be unnecessary.

4 million US dollars is not the final expense, and victory is not the inevitable result. Think about how depressed it would be if you spend more money and you will eventually get a loss or settlement.

If you spend so much money, if you spend it hard to exchange it for RMB, you can get more than 30 million yuan, which can be used to buy a house in Beijing, and you can buy hundreds of courtyard houses, and easily sell it to 10 billion yuan in 30 years.

Perhaps it is not as valuable as the $3 billion worth of PCR, but that is much simpler.

After all, to achieve a PCR value of US$3 billion, efforts and management are still indispensable. It is much easier to place the house there.

Why are Chinese companies unwilling to go to the United States to sue? Why are Chinese state-owned enterprises rather suffer losses than appeal? Just calculate the economic accounts and you can understand it. If a top leader of a pharmaceutical company spends $4 million to sue and then accidentally loses, it will be a loss of career. Even if you win, you will probably stop on the road to officialdom.

However, the rights and interests of PCR belong to Yang Rui’s private individuals, and Yang Rui could only grit his teeth and sign the check book and hand it to Yue Ting.

Yue Ting carefully checked the signature and spelling, and said funny: "No problem, I will save it in the Cayman company."

The offshore company in the Cayman Islands is Huarui's superior company. Above the offshore companies in the Cayman Islands, there are also multi-level offshore companies, which jointly help Yang Rui control Huarui while hiding himself.

"Please," Yang Rui put down his pen and said with a silent smile: "I really never thought about being a lawyer's fee of more than 1 million US dollars."

"The fees for lawyer Benjamin are high, but they are indeed amazing. Hong Kong companies are suing in the United States and generally cannot hire such a lawyer." Yue Ting smiled and said, "In recent times, it is best for us to keep in touch. I will report the quotations of various pharmaceutical companies to you at any time, and you can also notify me after making a decision."

"Okay." Yang Rui nodded: "I'm not at Peking University in the past few days, but I'm in Huarui Laboratory."

"Peking University is too wide. It's best to be in places with phone calls."

"There is a phone number in the Ion Channel Laboratory, but if I go to class or stay in the dormitory, there is nothing I can do."

Yue Ting thought intently. From his perspective, it is indeed very important to find Yang Rui in time. He can negotiate on behalf of Yang Rui, but important issues cannot be decided for Yang Rui. If it takes several hours to find someone every time, the progress of the negotiation can be imagined.

If a guy like Arnold appears again and gives an hour to decide the time or something, Yue Ting doesn't know what kind of losses it will cause.

After thinking about it, Yue Ting slapped his forehead and said, "Can we get a pager? The pager is a bit like a phone, but it can only call people in one direction. When you see the number, you will know that someone has been looking for it. The machine is not big, it is smaller than a slap..."

"BP machine?" Yang Rui was even more surprised than Yue Ting: "It's there now?"

"There is a name called, you know?" Yue Ting shook his head in a flash and answered Yang Rui's question directly: "I heard that Shang@hai has just started a public paging website this year. Beijing is currently working on it. I don't know if it is done well. However, some units have their own paging stations, such as hospitals and customs. I think, can they join which self-organized wireless paging website through people?"

Yang Rui looked at Yue Ting with a strange look and said, "You know more about technology than me."

"Where are, I just care more about things that can save time." Yue Ting smiled silly.

Yang Rui complained in his heart: "I mean the technique of pretending."
Chapter completed!