"We already know that the structure of the G protein-coupled receptor is a transmembrane structure composed of 7 α helixes. Not only that, some of its receptors also contain the N-terminal extracellular or the C-terminal intracellular structure. This makes the structure of the G protein-coupled receptor extremely complex."

Yang Rui held the microphone and slowly expressed his views.

Below the podium, there are nearly 300 scholars sitting in a dense seat, and there are corresponding academic media listed.

This was originally just a project application meeting for 863. Somehow, the scale increased from 9 judges to nearly 300.

In fact, Yang Rui knew what was going on. This was an application for G protein-coupled receptors. If scholars in related fields were not curious, then the Chinese academic community would collapse.

If you want to give a metaphor that meets the public's habits, in China in 1986, you will apply for a project "G-protein-coupled receptor" as if the Space Administration held a project review meeting, and the project reviewed was the "Sirius Landing and Colonial Plan".

Of course, everyone knows that Sirius landing and colonization cannot be achieved overnight, or even impossible. However, since the applicant is the famous "Yang Rui", even in order to know what the future prospect will be in 300 years, everyone is still willing to listen.

In fact, it is hard to say which one is difficult to study and what is happening with G-protein coupled receptors.

Even if Yang Rui only took a small step, it was enough for everyone to listen.

However, Yang Rui didn't just want to take a small step.

He held the microphone and looked at the crowd below. These may represent the highest level in China's protein field, and said with a clear voice: "Some structural biology studies have obtained structures of lower resolution, allowing us to see the general direction of G-protein-coupled receptors, but these structures are too rough and there are too many problems that cannot be explained."

"I hope to explain some of the problems." Yang Rui was not arrogant and had no intention of being humble at all, and said: "The questions I want to explain are as follows. First, why are hundreds of different molecules in the G-protein-coupled receptor family able to specifically identify substrate molecules ranging from photons to proteins, and these substrate molecules, in terms of shape, properties and volume, have huge differences."

"Second, I want to know, the signaling problem of receptors."

If Yang Rui said the first point, the scholars here could still watch him perform with a smile, but when they heard the second point, everyone was already talking.

Because Yang Rui simply raised two different questions and different directions.

Studying structure or studying signals is two links and two levels of difficulty.

Those who make structures will not go to make signals, and those who make signals will not go to make structures. Although they are all in the protein field, they basically belong to two branches. Moreover, these two are difficult to compare with each other, so why do you need to do it at the same time?

Including 9 senior scholars who were judges, they are now frowning at Yang Rui.

If Yang Rui is gone.

Of course, he knows that the two problems of structure and signal transmission are very difficult.

In fact, as long as you make any one, you may win the Nobel Prize.

The merger of the two means a complete Nobel Prize. According to the "Nobel Prize Foundation Charter", the Nobel Prize can be awarded to three people at the same time. In the fourth section of the "Regulations", it stipulates as follows: "Awards can be scored for two tasks, and each task must be worthy of the award. If two or three people jointly complete a work worthy of the award, the award should be awarded to them at the same time. But in any case, a prize cannot be awarded to more than three people at the same time."

Before the 1980s, or earlier, before the 1960s, the Nobel Prize was often awarded to one or two people. However, with the development of science and technology, as the importance of the Nobel Prize has increased, it has become the norm for three people to award prizes.

For example, what Yang Rui is doing now is that the structure and signal of G protein-coupled receptors should have been shared by American scientists Lefkovitz and Kbilka.

But that happened in 2012.

Since Yang Rui chose the model of research in advance, he naturally no longer wants to play the model of sharing.

Furthermore, only by making the structure and signal together can we roughly understand the G-protein-coupled receptor, which is indispensable.

If Yang Rui only did one of them, he still might be able to win the Nobel Prize.

G-protein coupled receptors are different from other fields because this field is too difficult, so accumulation is certainly necessary, but sometimes it depends on luck and inspiration.

Therefore, the Nobel Prize in 2012, the Nobel Prize in 2002, and even the Nobel Prize in 2012, are not too far away. At least for Yang Rui, it is not an insurmountable distance.

Of course, the chances of winning this thing are also very high.

It is normal for a normal Nobel Prize to wait for ten or eight years, or twenty years to win the prize. If you are unlucky, you will not wait for the award to be presented until the light is out. If you are faster, you will get a chance if you wait for a few years.

However, G protein-coupled receptors are very powerful. As for the 12-year version, the results were obtained in 11 years and the awards were awarded in 12 years.

There is no way, this thing is too kingly.

Of course, this does not mean that if you make a G-protein coupled receptor, you will definitely win the award in the second year. It can only be said that you have added another weight.

Winning Nobel Prizes is the same as fighting magical outfits.

You know that the boss will have magical equipment, the ultimate boss is a high probability, the big boss is a small probability, and the small boss has a chance, so the correct way to brush is not to brush an ultimate boss and look at the face, but to pile up the bosses and pile up the corpse mountain. The magical equipment will eventually fall into your hands.

Yang Rui is not very confident in luck, but he is still quite confident in his ability to win a boss.

After talking about a few more points, Yang Rui returned the microphone to today's host, who is also the project's recommender, Academician Zhu.

"Thank you Comrade Yang Rui. Next, the judges who have questions please ask." Academician Zhu's voice was lazy, and his eyes were curiously circling on the faces of a group of people.

He wanted to know how many people really understood.

The judges sat upright together, and the few people made noises for almost the same time.

"You can do it first."

"You ask first."

"After you."

Several people were humble again and again.

Afterwards, Professor Qian, who was sitting among the judges, said: "Yang Rui, your plan looks good, is it a bit too grand?"

"It is indeed a grand plan, but I am confident that I can complete this plan through Peking University Ion Channel Laboratory and prove that the Ion Channel Laboratory is a world-class laboratory."

Wow.

The scholars in the stands started to talk again.

Yang Rui just nodded slightly, looked at Academician Zhu, and turned around and said: "Peking University Ion Channel Laboratory has raised US$6 million and RMB 2 million in funding. This time, he applied for a total funding of RMB 3 million from 863 Plan to enhance our strength..."

Yang Rui showed his sharpness and no longer had any intention of being modest.

Standing on the kingly way and rushing forward, everyone will see you, and no matter how timid you hide it, you can't hide it.

And the sharp edge with $6 million as the corner is really something that many people can't resist.

Professor Qian couldn't help but sit down quietly.

He will only humiliate himself if he asks questions again.

"Next, who has any questions?" Academician Zhu asked softly.

Nine judges shook their heads together.

"Then vote now. Those who agree to pass the project and the application amount, please raise your hand.

The nine claws were raised together.

"Okay, I announce that the first project of the National High-Tech Research and Development Plan, the structure and signal of the G-protein coupled receptor, has been officially passed. The person in charge is Yang Rui of Peking University..." Before Academician Zhu finished speaking, applause rang softly.
Chapter completed!