Sleepwalking is often heard in scientific stories, most of which are touching the scene and feeling in the sleep.

The discovery of benzene ring, the invention of PCR, and even the discovery of DNA double helix are all successful cases of sleepwalking.

The researcher returned to the middle of the night and woke up in a sleep, and solved the problem that had been studied for a long time. This kind of model, which is somewhat like an epiphany, is very popular among various scientific stories, and ordinary people are also very paying for it. The information he implies is that ordinary people can actually make excellent scientific research results.

Therefore, young people, middle-aged and elderly people who are interested in science will smile at the scientists' sleepwalking stories.

Of course, ordinary people cannot actually produce outstanding scientific research results.

Ordinary people can make some small inventions and add an eraser to the pencil, which is no problem, but the coverage of basic science has exceeded the ordinary level. Many people who have studied PhDs cannot access cutting-edge science in the world, let alone the actual discovery process, still have to follow the scientific process.

However, the second of the sleepwalking method is that it is a reasonable and legal reverse - I think the double helix is ​​very handsome, so I'll try it out. It turns out that the double helix is ​​really good, which is the best guide to using the sleepwalking method.

Yang Rui hopes to create a three-dimensional structure of the G-protein-coupled receptor. The first step is to create a conformation of the transmembrane region of the G-protein-coupled receptor.

To be honest, such a conformation is worth half a Nobel Prize.

If a biologist with sufficient foundation, it would be almost enough to win the Nobel Prize for a conformation of a transmembrane region of a G-protein-coupled receptor. Of course, it would be correct to share it with others.

It is such an important scientific achievement, but the conformation of the transmembrane region of the G-protein coupled receptor is a very simple image when it is displayed in public.

Just like a DNA double helix, it is formed by two snakes, the conformation of the transmembrane region of the G-protein-coupled receptor can be described as an image of 7 springs stirring up.

"Molecules that can transmembrane seven times" are powerful protein molecules comparable to Seven Times in a night. They may be the most powerful molecule in the human body, but in the end it is composed of seven tentacles, each tentacle still looks like a thick spring silk, and the image cannot be said to be beautiful.

However, such images are not something you can have just want.

The tentacle monster composed of seven tentacles is easily drawn, but the structure of the G-protein-coupled receptor must stand scrutiny.

Yang Rui was preparing to use sleepwalking techniques, not really planning to go to sleepwalking. It is in line with the current cognition and judgment of the scientific community.

This is what Yang Rui was searching for.

He has to see what basis he has for "sleepwalking".

The three intracellular rings and three extracellular rings were understood in the 1950s and 1960s. The first two intracellular rings are smaller, while the third intracellular ring is larger was determined after several years. As for the transmembrane helical sheet of the receptor, helical I-IV forms one sheet and helical V-VII forms another sheet. This understanding is relatively new.

In addition, the most important thing is the image data illuminated by electron microscopes and X-rays.

Although protein is such a small unit, the technology from the 1980s is enough to take a rough look.

However, the transmembrane conformation of G protein-coupled receptors focuses on the two words transmembrane.

What scholars want to figure out the most is why G protein-coupled receptors can cross membranes, and they cross seven membranes.

This is also the core problem that needs to be solved in its transmembrane conformation.

Yang Rui was looking at the information while making sketches on paper, but it was completely opposite to what other scholars did.

Scholars of this era, studying the transmembrane conformation of G-protein coupled receptors from scratch, first fantasize about the placement of seven tentacles in their minds, then consider the relationship between them, and then examine whether they match the known structural information and explain the inconsistent parts...

This is a very tedious and meticulous job.

The DNA double helix structure has only two strands, which makes multiple laboratories want to die. There are 7 strands of G protein-coupled receptors, and you can imagine the difficulties.

However, what Yang Rui has to do is not addition, but subtraction.

After 30 years, the transmembrane conformation of the G-protein coupled receptor is confirmed, and the three-dimensional structure is confirmed, let alone the first step of conformation.

But Yang Rui could not directly take out the conformation of later generations because of certain restrictions that the academic community does not know about now.

At the same time, Yang Rui also had to determine the research progress of his laboratory and reached a corresponding level. It is best to infer conformational data from the research progress of this laboratory - it is to draw pictures, but in the final analysis, all images must be expressed in numbers.

And numbers, numbers naturally need to have some foundation.

Yang Rui turned out all the information and barely collected 70% or 80% of the content. As for the rest... he naturally had to force others to do it.

"When I was sleeping last night, I thought about it carefully. The handover of the 7 spiral chains must have a certain effect. I tend to think that they are used to identify substrates, and they are specific substrate molecules..." Yang Rui said while writing two lines of words on the blackboard of the laboratory:

1. Determine the contact between the 7 helixes and substrate molecules.

2. Describe local conformation according to substrate molecules.

The simple words are like a container smashing on a jeep, which makes everyone breathless.

"When you sleep, do you think of these things?" Gu Qiang looked at the two questions and wanted to complain.

Yang Rui nodded steadily. The best way to sleepwalking is to explain the idea simply, and it eliminates a series of logical problems.

Gu Qiang was helpless, curled his lips and said, "I'm just wondering, how can you sleep."

Yang Rui coughed twice and said, "If you give the answer, I will definitely be able to sleep."

"There is no ready-made solution, right?" Professor Manhai asked.

"No."

"So, all depends on trial?"

Yang Rui shrugged.

To test the contact between seven helixes and substrate molecules, we naturally need to use substrate molecules and G protein coupled receptors to test. There are hundreds of substrate molecules, and the test is naturally tens of thousands.

Professor Manhai only felt the darkness in front of him and murmured: "No wonder you asked them to make so much cattle rhodopsin protein."

"It's still our advantage period now. Everyone should work harder. When the project is over, everyone can go abroad." Although Academician Zhu came forward to do his work and the trip abroad was rejected, it was still a very bad thing, and Yang Rui could only take the opportunity to draw a cake.

Manhai also took the opportunity to show his loyalty and said, "As long as it can be done, it doesn't matter whether he goes abroad or not."

"It is the focus of the present." Yang Rui quickly raised the topic and said: "I have already initially had some ideas on conformation of G protein-coupled receptors. I hope everyone can do their work well and contribute to the completion of the project..."

Yang Rui did not take out his sleepwalking composition as a whole, but he still made a few simple partial pictures and handed them to several researchers.

A group of people started to study it silently, some of whom couldn't understand it, stared blankly, and some of whom could understand it, and began to look for old materials to compare it in a daze.
Chapter completed!