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Chapter 1373 Enzyme Substitution Method

"Uncle, please ask, Director Yang is here." With a 30-minute translator, he came to the door of the ion channel laboratory, and with a smile on his face, he handed a cigarette to the doorman Mr. Qin.

Uncle Qin took it over without hesitation, looked at it, and found that it was all in English, so he put it in his mouth, and said in a vague manner: "The conditions are good, you can afford to smoke even outside."

The translator quickly lit a cigarette for him and said with a smile: "If you do something for a foreign company, you have to decorate your storefront."

"Well, the taste is strong enough, and it has a little bit of the power of the smoke pot." Mr. Qin commented.

The corner of the translator's mouth twitched twice, and thought to himself: If you want to smoke a pot, you should say it earlier. I'll weigh a pound of loose cigarettes for you.

Uncle Qin sucked one-third of the thread in one breath, spit it out, nodded comfortably, and said, "Which unit are you from? What's the matter with Director Yang? Have you made an appointment?"

While asking questions, Mr. Qin opened the registration book and pushed it to the translator, and said, "Foreigners also need to check the ID. We are a confidentiality unit here, please know."

"I know." The translator glanced at the police booth next to him, and the armed police soldiers who came to him at some time, and asked with some confusion: "When will the armed police stand guard in our ion channel laboratory?"

"Making new drugs is as much money as the sea. Can it be possible without sending armed police?" Mr. Qin looked as if he were right.

In terms of the value of new drugs, the cost and profits of tens of millions of yuan are indeed more than most state-owned enterprises in China. Sending an armed police to stand guard is not out of line. However, the ability to make changes so quickly is something that the translator cannot understand.

Fortunately, the foreigners didn't understand even more. The translator filled out the registration book, so he turned around and smiled at the client: "Mr. Liandell, the Peking University Ion Channel Laboratory is a government-invested laboratory. They dispatched police just to ensure its safety, and did not restrict foreigners' access, nor would it have an impact on your residence in China."

"Are you sure?" Liandell was a yellow-haired foreigner with a little white hair. His eyebrows were stretched out like an inch on his forehead, and he was trimmed with great care.

"I'm sure." The translator gritted his teeth and gave an answer. He was afraid that the foreigner would regret it and the voice was bleak, so he hurriedly said: "Director Yang is now in the laboratory. I just registered, but we ranked sixth today and may not be able to see you. We have to call to confirm later. Why don't I take you to play for an afternoon and come here tomorrow?"

"Mr. Yang Rui must be very busy now. Please confirm with them again. I really want to cooperate and maybe meet in advance." Leander said as slowly as possible, so that the translator could understand what he said.

The translator was stunned for a moment and smiled and said, "Okay, then I'll discuss it again, but people said that there is no time today, and Director Yang will not receive guests today."

Leander nodded silently.

The translation is a bit weird, but I feel a little proud in my heart. Although it was easy to cheat foreigners in the past, they were called around and drunk. After all, they had to endure foreigners' unreasonable interpretation of Chinese culture and history. Although they are a bit keen on others, they are foreigners asking for Chinese people. He is just an intermediary and feels excited.

After asking a few more specific questions, the translator came to the front of the concierge, muttered for a long time, turned around and asked Leander: "Would you like to meet Yang Rui with others?"

“See you together?”

"I said you are the manager of a pharmaceutical company, and the other party said that if you are willing to be with the managers of other pharmaceutical companies, you can do so in advance, otherwise you will have to wait."

Liandell looked at the doorman Qin suspiciously and asked, "Does he have such a right to make this decision?"

"Maybe it was decided long ago in the ion channel laboratory."

"Okay, if we meet together, can we meet Yang Rui today?"

The translator shook his head slightly and said, "It can only be tomorrow afternoon. Or, I will take you to the Forbidden City to take a look. There are many Chinese antiques and cultural relics in it."

"What will Mr. Yang Rui like? Let's buy something he likes." Leander said purposefully.

The translator opened his mouth, nodded, and said, "Then go to the Friendship Store."

The next afternoon.

Leander had a simple lunch and took the canned food and malted milk sperm he bought from the Friendship Store to the Ion Channel Laboratory.

From personal experience, Liandell doesn't believe that Yang Rui would like canned food and gluten, but the translator said that this was a high-end gift given to each other by Chinese people, so Liandell believed it. After all, what country does not have any hobbies?

Yang Rui was a little confused when he received the gift from Liandell in the living room. He said that there are also foreigners who tried to bribe these days, but using canned food and wheat milk essence, it is not suitable for buying it from the Friendship Store.

"Mr. Liandell, please wait a moment." Yang Rui could only put the canned food and wheat milk sperm on the table and reminded the scientific research dogs who helped in the conference room to bring them back to the foreigner later.

Liandell was very happy, feeling that Yang Rui had accepted his gift, so he asked boldly: "Professor Yang, which other pharmaceutical companies will participate in the talks?"

"Green Stone Corner, Glenski, and Jelicon are sure to participate. I'm not sure if the other companies will come." Yang Rui casually said a few names.

However, Leander immediately felt the threat of the enemy coming.

Compared to his Kaliz Pharmaceuticals, Gelicon and Glenski are both behemoths.

However, Leander had no chance to speak. He just raised his hand to look at his watch and several blond, brunette or white-haired men walked in.

Yang Rui was a little funny. Europeans and Americans have not started to play with diversity yet. So, on both sides of today's conference table, there are all white men sitting. Not to mention that there are no people of color, there is not even one woman.

Pharmaceutical companies in the 1980s were pure patriarchal politics. If it weren't for this, there wouldn't be any organization to carry out women's public relations projects.

Yang Rui was thinking so randomly, and waited for everyone to sit down, and said, "Everyone's time is precious, so I'll tell you straight to the point."

He used Chinese, and he had his own translation next to him to worry about how to translate straight to the point.

After the latter said it in a string of English, Yang Rui said again: "You all came to the ion channel laboratory today and are interested in the medicines in this laboratory. Considering the professionalism of the medicines, I have prepared some booklets for you to show. Well, after reading them, please return the booklets."

After saying that, someone began to distribute black and white printed paper products.

"Gache disease?" Leander opened the booklet and saw this proper noun.

"Yes, glucerebroside disease. According to European and American classifications, this is a rare disease. The current number of patients is not many worldwide, roughly around hundreds of thousands." Yang Rui paused and said: "So, in order to balance expenses, the partners I need should be able to apply for rare diseases, preferably companies with experience in selling rare diseases..."

Yang Rui said hundreds of words before letting the translator say it.

Representatives of several companies did not pay much attention to this aspect.

Large pharmaceutical companies are all very good at hand, even if they are transnational politics, let alone the compliance application in their hometown.

The key point they really focus on is still whether Yang Rui can produce new drugs.

"What kind of solution do you want to adopt to develop the drug for Gaucher disease? What is the current progress?" Glenski's manager put on glasses and dragged it lightly, looking a little smart.

"Enzyme replacement method." Yang Rui answered without hesitation.

Gaucher disease is a disease caused by gene mutations. In the final analysis, it is the lack of glucetazolidesidase. Because the structure of glucetazolidesidase in the patient's body has changed and cannot perform its due functions, the human body has a series of symptoms, such as spleen enlargement, anemia, bone lesions and nervous system disorders.

In theory, supplementing with sufficient amount of glucosidase can improve the symptoms of patients with the disease.

However, this is obviously not an easy task. RB enzyme has no effect at all at this time.

Glenski's manager also looked at Yang Rui with a skeptical look and asked: "The enzyme replacement method is said to be extremely costly. Can it be used for drug-grade production?"

"Just reduce costs, I'm still very confident in this regard."

Yang Rui's expression was also full of confidence.

Developing new drugs is no stranger to Yang Rui.

To be honest, no more than 200 scientific research institutions around the world can have the proficiency of Yang Rui.

The reason why I am so sure is that there are not 200 new drugs developed by people all over the world.

Don’t see that in the 1990s, there were more than 4,000 new drugs developed in the entire Western world, or the world. However, the real new drugs are new drugs made of a brand new compound rather than an isomer of an old compound, and the total number is more than 100.

Deferrosterone is one of them.

Although Yang Rui did not operate the entire process until the deferrosterone was launched, there were actually not many new drugs that could be done after the second phase of clinical practice. Unless you had to cheat, new drugs starting from the third phase were basically outsourced to specialized companies for clinical experiments. There are thousands or tens of thousands of clinical patients, and what they need is a clinician, not a drug developer. At this time, developers cannot modify the composition of the active substance, and in fact they can only leave it to fate.

After a fateful choice, deferrosterone is already facing the market. The development of a new drug has been completed so easily, but it has not been repeated many times. To be honest, this result has shocked some analysts.

Now, with the addition of the Nobel Prize, Yang Rui's success is a bit natural. The news that Peking University Ion Channel Laboratory is trialing new drugs has attracted so many pharmaceutical companies at once.

However, it is one thing for pharmaceutical companies to be interested, and it is another thing for investment or cooperation. Leander glanced at Glenski's manager again, hoping that he could ask Yang Rui further inquiries in order to get more information and make a judgment.

Glenski's manager, indeed pondered for a few seconds, looked up again and said, "We Glenski are willing to invest $1 million to obtain 10% of the drug's future equity. Is this OK?"

Leander almost fell off his chin, so he gave money? Are you so rich and powerful?

Leander quickly looked at the others, and saw the manager of Green Stone Corner, Shi Ran said: "1.5 million US dollars, 10% equity!"

Just one round of bidding increased the price of new drugs that Yang Rui had not started yet by 5 million US dollars.
Chapter completed!
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