Shotgun is not the best gene sequencing method.

Its accuracy is poor, so, another translation name for it is shotgun.

Don’t count on where to hit, one hit and one hit is its feature.

In the eyes of the most traditional biologists, such a method is actually not very popular. Because it is contrary to intuition and has problems with accuracy.

Sanger sequencing is the sequence of each gene, which is completely in the order of gene arrangement. This advantage is that the sequence of a gene will be completed and your map will be a little more complete.

The Human Genome Project is based on this. Watson and others fantasized about using $3 billion to make a human genome map of the average price of $1 dollar per human gene.

Of course, they also know that with the current sequencing difficulty, sequencing one gene is not enough for one dollar, but it is just a fool anyway. Considering the dividends of technological progress, the costs saved by various costs, and the additional costs in the later stage, it seems that it can be completed.

It just cannot be completed - isn't Dalbeko's cancer conquest plan not completed? If it is not completed, it will not be completed.

Compared with the Sanger sequencing method, which takes one step at a time, the technical characteristics of shotgun are actually more prominent, but they are also a little more troublesome.

The shotgun technique is to shoot one shot and knock a gene chain into pieces.

It was like a dog chain. When a shotgun came out, it was naturally dismantled into metal rings, and then the ATCG of the metal ring was measured in one breath.

At this step, it is very simple, and it can be said to be a shot.

The next step is the steps that Dalbeco and others dislike the least.

You need to rearrange the metal rings into the original order and rearrange a dog chain.

This step is very difficult, so in history, shotgun was originally used for microorganism sequencing. Because the genes of microorganisms are simple, they are easy to arrange.

After changing to the human genome, sorting it by shooting marks is much more difficult than puzzle games.

unless--

"We use computers to solve the problem of unsequential shooting of shotgun." Yang Rui stood in Huarui's laboratory, and without thinking, he told the direction of the experiment.

Huarui Laboratory is his private laboratory, and all rights are in his hands, so there is no need to worry about anything.

However, Huang Mao said with some concern: "It costs a lot of money to do a human genome plan. Can you make it back?"

Yang Rui laughed and said, "When did you care about the funds?"

"Aren't I afraid that your company will go bankrupt?" Huang Mao said naturally: "I heard that the bankruptcy law has begun to be implemented, and insolvent companies will go bankrupt."

Two years ago, several state-owned enterprises were forced to collapse in China, and they reported it extensively, and they were the only ones that collapsed in the 1980s.

"We are still far from being insolvent, so you can rest assured."

"I want to rest assured, but I'm afraid that your follow-up funds won't keep up." Huang Mao said casually.

"There will always be a fund when it is needed, so start to do it first." Yang Rui was thinking about his hundreds of courtyard houses, and more than 20 buildings in a commercial community I just bought, and houses of antique tea and stamps. He always felt that he was rich.

Of course he is rich, according to the standards after 30 years.

But in the late 1980s, although houses in Beijing were still out of reach for ordinary people, it was not enough for scientific research. Even if you sold the newly bought commercial community, that is, the daily funds of Huarui Laboratory for several years, you should not even think about the bottomless pits like the Human Genome Project.

If you think so, I have to thank the rising housing prices. In later research institutes, there are actually many dormitories for distribution, and the family property of researchers is mainly concentrated on self-occupied real estate. The speed of their asset appreciation really exceeds the speed of technological development... In theory, if some large research institutes sell all the land, they may be able to research their own human genome plan...

Yang Rui’s thoughts cannot be known to Huang Mao. The latter listened to Yang Rui’s words and shook his head slightly and said, “It’s okay to listen to yours, but you have to pay attention. If you want to pre-research on the Human Genome Project, I don’t see any possibility of giving back funds.”

Pre-research is purely basic science, and there are very few funds to say that the funds are given back.

If it weren't for the later Salalah Genetics Company, to be honest, Yang Rui wouldn't be sure that the shooting technique could be sold for money.

In fact, Salalah Genetics Company was not really successful. Although its leader, Ventel, had fooled $300 million, developed shotgun techniques and used them in the human genome project, and tried to register human genes as patents. If he succeeded, any targeted drug in later generations might be outrageously expensive.

Salalah Company will probably be really rich.

Unfortunately, Comrade Wentel did not succeed.

So, to be honest, the human genome project really has no history of making money.

The pharmaceutical companies that made money later did not give the project team of the Human Genome Project, and gave a penny reward.

However, if Americans cannot make money, it does not mean that Chinese people cannot make money.

At this time, the benefits of independence are reflected.

As for Yang Rui's current status, in the case where cutting-edge technologies involving biology and no ready-made laws can be used, he almost finished the formulation of new laws and regulations.

GMP committees and other things are all of the same nature.

If you don’t let top scientists like Yang Rui make a judgment, would you find a liberal arts student to guess?

Many people think that clones are really copying a person.

In fact, the difference between cloned people and IVF is only at the genetic level. You still have to conceive ten months, give birth naturally or have a caesarean section, and then get educated like a normal child. If you want to get the same Hitler or Einstein, it depends on whether your parents have the ability!

Qualification to participate in the formulation of laws is an implicit power of top scientists.

From the perspective of a person's needs, why are so many people willing to immerse themselves in the painful and boring world of science? Some of them really like this world of science, while others use this as a springboard to enter the power class in one breath.

For example, some famous economists in the 1980s and 1990s played a greater role than many ministers and truly changed China.

It is hard to imagine that people who suffer in stocks, are happy for stocks, and are frustrated for stocks. This stock market has been dependent on the reports of several people for twenty years.

Similarly, people who are troubled by hypertension, suffer from rheumatism, suffer from bone hyperplasia, and are out of breath for bronchitis, can live a few more years and live much easier, just like those who are valued diseases, such as diabetes and AIDS, whose living conditions in the 1980s, 1990s, 190s and 10s were completely different.

**The life of patients with dysfunction has been completely changed by the blue pill.

Before the Blue Pill, many men's invisible hidden secrets were really hard to say, and they could not save them. After the Blue Pill appeared, most men were embarrassed that their hairlines were gradually moving, and they could not hide them even if they wanted to.

"The funding issue cannot be ignored. Well, if you are really worried, let's prescribe another group and make antihypertensive drugs." Yang Rui was undoubtedly preparing to pull Viagra out.

The Human Genome Project is a money-intensive project, although Professor Cai promised to help find money, Yang Rui himself could not relax.

As he said, the allocation is determined by the proportion of funds, and it still needs some effort to ensure control.

If you find something that costs less money and takes effect quickly, you will naturally think of Viagra.

Of course, the main ingredient of Viagra today is still being used as an antihypertensive drug test.

Huang Mao did not doubt that he was there, and said, "I will be too busy to prescribe a set of antihypertensive drugs at the same time."

Yang Rui has made many new drugs, and he makes a lot of money every time. It is not surprising that he makes medicine for money. He is only worried that Huarui's scale cannot support two projects.

Yang Rui shrugged and said, "I am more interested in the discussion of nitric oxide now. I am going to buy a compound to make it."

“Huh, do we buy compounds?”

"Well, I'll find someone to buy it, you don't have to worry."

Huang Mao smiled bitterly: "Why aren't I worried? In the past, we made active compounds and sold them to pharmaceutical companies for clinical trials? We don't have the experience in clinical trials..."

"Everyone has the first time." Yang Ruicai said generously: "We have money, don't worry."
Chapter completed!