Pharmaceutical companies are very willful in the Jinyuan world. If Yang Rui is a Chinese American or something, let alone discussing business with Pfizer, he will have to thank the Lord for being recruited by Pfizer.

If you don’t do it well, a group of lawyers will pounce on you and make you doubt your life.

Nowadays, Yang Rui is the head of the ion channel laboratory, the owner of Huarui Laboratory, Yang Rui Genetic Engineering Laboratory I, the inventor of PCR, the pioneer of the human gene era, the king of G protein coupled receptors, the breakthrough of ion channel, the Nobel Prize winner, the real king of genetic engineering, the controller of cow embryos, the developer of Chinese medical standards, the pioneer of the 863 plan, the rescuer of millions of patients with arrhythmia, the male god of Chinese and foreign media, the father of cloned sheep, the terminator of thalassemia, the expander of coenzyme Q10, the lightning rod of the Chinese scientific community, the supreme monarch of sixty-four experimental dogs...

As a pure Chinese and Chinese scientist, with the back of this big tree of China, he can fight foreign and state-owned enterprises in minutes to doubt his life together, or formulate policies to make pharmaceutical companies that want to develop in China look up at the stars and lament the injustice of the world.

Being a big boss in China, a closed and huge market economy country, has such benefits. Unlike Japan and South Korea, if you want to establish a drug closure policy, you have to consider the implementation of security regulations.

To be said, how strong is the strength of pharmaceutical companies, especially the Jinyuan? Needless to say, it is necessary to influence the policies of their own country, but it is also common to affect other countries. In order to unite with insurance companies to make money, they can change their medical insurance policies and make people die.

However, China has never been a country that plays according to common sense.

Even if Yang Rui didn't make a fuss, Pfizer would still encounter many problems in China. For example, the name "Viagra" was snatched by domestic companies, but the result was that the lawsuit had been fought for several years and there was no result. Until the end of the patent period, Pfizer could only be named after Viagra.

The problems Pfizer encountered did not end here. After Viagra's patent expired, domestic Jinge raised the banner of competition. In addition to advertising, their most ruthless move was to inject Viagra into the prescription drug industry.

For a long time, Chinese people who want to buy Viagra need to prescribe a prescription before they can buy it, while Chinese people who want to buy Jin Ge will go to any small pharmacy and take the money to get what they want.

Is this competition legitimate? At least at the policy level, this is the result of the competition.

Whether a drug can be launched on the market, whether it should be included in the list of prescription drugs, whether it should be produced in the country, whether it must be produced in the country, and whether it should be conducted further testing and clinical trials are ultimately decided by the bosses of various committees.

Faced with a market with an average annual growth of more than 10% by 1.2 billion people, Pfizer is easily unwilling to offend the big guys.

In order to make up for the relationship, Pfizer even spent money to hire a China Communications Commission and went to China to negotiate with Yang Rui.

"Franke? Why are you here on behalf of Pfizer? You are not doing it at Jielikon?" When Yang Rui saw the representative of Pfizer, he was stunned for a few seconds.

He hasn't seen this British fat man for a while.

Frankie smiled like a cracked donut and said, "I opened a special consulting company to provide services to pharmaceutical companies about China, and my income has increased several times."

"Have you become your boss? Awesome!" Yang Rui gave his thumbs up to his old acquaintance Comrade Franky.

He likes this fat British man very much. Compared with the common foreigners with arrogance and prejudice today, Frank is much more sensible and communicates better.

Franky can eat this bowl of rice because he relies on everyone's love for him.

Seeing that Yang Rui agreed with his choice, Frank was so happy that he used the Chinese he had just learned, raised his tongue and said, "It's all up to brothers to support him!"

Yang Rui laughed haha, and bit Franky, saying, "Just relying on your hard work in learning Chinese, I want to treat you to dinner. Well, go to my laboratory. I'll let Mr. Yu take charge of it."

"Chef Yu's craftsmanship is three-star." Frankie became greedy as he said. He was talking about three-star Michelin, and his highest state was in his highest state.

"Yes, you've eaten the meals made by Chef Yu, that's great. I'll save the introduction. Do you want to order food?" Yang Rui showed Chinese hospitality. He didn't feel that way to a strange foreigner.

"Please choose Chef Yu." Frankie paused and said, "If you can, I want two of the stewed lion heads."

"Well, there are two stewed lion heads with big fists. Please choose the rest. Chef Yu, there is one..." Yang Rui looked at Frank's wider figure and said, "There should be seven or eight dishes, and it should be almost the same. The portion is a little larger."

Frankie nodded after hearing the translator's whisper: "Daf, big portions are good."

Neither of them wanted to talk about business, but Pfizer's manager Conneill was extremely happy and thought to himself that the six-figure expenses were finally not in vain.

Chef Yu is older and has less time to cook in person, but more time to think, and the dishes he makes taste has gone to a higher level.

However, most of the dishes are cooked by his apprentice.

He is said to be an apprentice, but now he is a chef. He is also a celebrity in the kitchen industry. Whether it is frying, steaming, it has personal characteristics.

For example, Frankie's favorite stewed lion head is the traditional method of cutting pork ribs into pomegranate seeds with a flat knife. The best ratio is to be fat seven or thin three. However, Chef Yu's second apprentice has begun to consider health factors.

The lion head he made was not as fat as his master. While using a ratio of 50% to 50% to slim, he also used ice water to skim oil, which not only maintained a tender and smooth texture, but also increased the proportion of lean meat, making the stewed lion head healthier and more suitable for people who are not short of meat.

Of course, there is no way to say that eating too much because it tastes delicious.

As for whether it is authentic or not, Yang Rui no longer cared about it.

Modern people who eat famous dishes and pursue authenticity are the most inauthentic. Authenticity can only be said to be in line with the taste of a generation, but if not done well, it is in line with the taste of a literati and poet. The least is also in line with the preferences of people in a region, and it is still quite far from being delicious.

From this point of view, eating authentic food is equivalent to queuing up in a travel line and taking photos with the words at the entrance of the scenic spot, and is for the purpose of friends.

"Professor Yang, why did you think of buying sildenafil?" To the point where you couldn't walk, Franzel leaned on the chair, touched his stomach with his hands, and asked with a smile.

"I am optimistic about the prospects of nitric oxide drugs." Yang Rui did not hide his approval, took a sip of wine, and spoke slowly.

Sildenafil is an active drug that has undergone animal safety testing. No matter how cheap it is, it costs tens of millions of dollars. If it is not recognized and optimistic, there is no reason to buy it.

Nitric oxide drugs are also the most popular type of medicine in the past two years. The so-called nitric oxide drugs are nitroglycerin, which is the explosive component of Nobel and is also miraculously effective for angina pectoris, but for a hundred years, people don’t know why.

It was not until the late 1980s, that is, in the past two or three years, that the biology community gradually understood that it was an organic nitrate enzyme such as nitroglycerin, which could increase the concentration of the second messenger in human tissues, and its effect was to metabolize nitric oxide.

This is a brand new signaling mode, which is a deep understanding of the self by human beings.

The word nitric oxide becomes popular as a result, and in a few years, you may even win the Nobel Prize.

Pfizer also conducted research on sildenafil, which screened a large number of molecules and finally selected this small molecule compound named UK-92,480.

It can be seen from its naming number that it is so troublesome to sift out a molecule.

Although Yang Rui believes that there must be other molecules that can exert similar or stronger effects, giving him tens of millions of dollars or even hundreds of millions of dollars is really not necessarily possible to screen them out.

Pfizer is unwilling to put it on the shelves because of this reason.

Nitric oxide drugs have just become lively, and now they are sold. If you want to sift out one available, it is really not easy to do so.

However, China is also a big market that has just become lively. It is not something Pfizer is unwilling to find a big obstacle when it opens the door.

Frankie took Pfizer's money and naturally wanted to speak for Pfizer. He also took a sip of the liquor, grinned and said happily: "Why are you interested in sildenafil? You have to do it? Isn't this causing Pfizer to ask for a sky-high price?"

On the surface, he was talking to Yang Rui, but in fact he was also raising the price.

Pfizer is still unwilling to sell it, but was forced to negotiate by Yang Rui. The first choice is to open a sky-high price.

Yang Rui was not surprised, holding the wine glass and said, "I chose sildenafil because it is the most safe among nitric oxide drugs. Huarui's first drug, not only has the efficacy, but also needs attention to safety."

"Hey, is this your business direction?" Frankie was immediately led by Yang Rui.

Yang Rui nodded and said, "That's right. Okay, let's talk about Pfizer's offer."

"You are so anxious, aren't you asking others to offer high prices? Why bother?" Frank used the same method again.

Yang Rui leaned on the chair, put his hands on the side, and looked like a big boss, saying, "Let's try it out."

"This..." Frankie was immediately shocked by Yang Rui.

His task is very simple. He contacts Yang Rui, eases the relationship, and gives a quote. If he angers Yang Rui and destroys the Chinese market, Pfizer will be unhappy and he will be blind.

"Connell, say it." Franky quickly found a scapegoat.

The Pfizer manager doesn't care. He didn't know Yang Rui at all and didn't establish any relationship. After hesitating for a few seconds, he said: "If you only sell sildenafil in the Chinese market..."

"There is no such thing. You are holding compounds in your hands now, not compliant drugs. Have I developed new drugs and only sold them in China? Am I crazy?" Yang Rui immediately interrupted Connell.

If a new drug is successful, it will cost hundreds of millions of dollars. There is no reason to sell it in one place.

If it can cure alien diseases, pharmaceutical companies dare to invest money to restart the Apollo plan.

Connill asked for a price all over the place and smiled: "You can hand over the market outside of China to us..."

"Agent sales will be a future matter. Let's talk about the compound transaction now." When Yang Rui really wants to sell the blue pills, he still needs foreign pharmaceutical companies to be an agency company, but that is a future matter. It is meaningless to talk about these before the drug effect is seen.

Connill just said it casually, and at this moment he couldn't help but look at Franky and said, "We have spent hundreds of millions of dollars to develop sildenafil..."

"If you spend time with me, there is no need." Yang Rui stood up suddenly.

"Professor Yang Rui, how do we develop in cooperation? If you are interested in sildenafil, we are willing to use open solutions to cooperate with you. The cooperation solutions can be very open." Connill said desperately.

For Pfizer, the Nobel Prize winners are also very attractive.

Especially Yang Rui, who has a precedent for developing new drugs and is a cutting-edge biologist who has made G-protein-coupled receptors. His qualifications are several planes better than Twite, the current head of sildenafil. It can be said that as long as Yang Rui is willing to cooperate and the terms are not too harsh, Pfizer is very interested.

Even if he has no achievements, then the new drug of sildenafil will be named as a Nobel Prize winner, and may be sold for hundreds of millions of dollars more.

This is also the biggest reason why Frankie can get a six-figure reward.

He immediately said, "Professor Yang, this is a rare opportunity. You can raise any conditions. Sildenafil has just done animal experiments and is still far from being launched. You may also sell it at that time. Why not start working together now?"

The drug that removes ferroster is a long-term recycling project. Yang Rui was too lazy to spend time doing it, so he sold it in a milestone way.

Even if Viagra wants to cooperate, it still needs to discover its true effects.

"Find someone who can make a decision and ask him to offer the offer." Yang Rui was not affected by Frankie's words and said again: "I can offer a high price, otherwise I will buy other types of nitric oxide compounds. If I develop it first, the value of sildenafil will be greatly reduced."

The greatest value of a new drug lies in its use of new mechanisms to treat diseases.

In other words, patients who were not well resistant to certain drugs in the past might be more suitable for taking new drugs. New patients represent higher sales.

Naturally, if similar drugs are first launched, the drugs that are later launched will inevitably be affected. Especially according to the rules of the US FDA, drugs that are later launched must be compared with drugs that are first launched.

If the drug is of equal or worse, the drug developed later cannot even be listed. For a company, the stock price alone will be hit.

This is a business decision worth hundreds of millions of dollars, something Connell could not make.

He immediately lowered his head and said, "I will notify the company headquarters immediately."

After saying that, he said quietly: "Mr. Yang Rui, I hope our negotiations will not interfere with Pfizer's business in China..."

"Of course it will interfere." Yang Rui is not a little white rabbit, so he said calmly: "A company that cannot make correct business judgments cannot do business well. You can retweet the Pfizer leadership in its original words."

"Professor Yang, I'll give you a cup." Franky was so convinced.

The more domineering Yang Rui is, the more he likes him. It is impossible for Pfizer to give up the market of one-sixth of the world's population. Yang Rui's obstacles are what they must pass.
Chapter completed!