After Yao Yue started working, he was still a little nervous.

But soon, she realized that she didn't need to be nervous.

Because Yang Rui was extremely serious in his work, he had no time to care whether her dress and white coat were really with him.

The workload of producing coenzyme q10 in plant extraction is too great.

Especially Yang Rui is ambitious and wants to build a R&D chain, the task is even heavier.

In order to finally produce cheaper coenzyme q10, the most important step is to extract the intermediate product solanol from tobacco leaves, and then use solanol as the intermediate product to synthesize coenzyme q10 by chemical method.

In fact, there are related technologies for extracting solanol from tobacco leaves.

Even the chemical synthesis of coenzyme q10 using solanol as raw material has been produced, and there have been relevant papers and laboratory results in 1959.

However, papers are papers after all, and research is research after all. Just like pure chemical synthesis of Coenzyme q10, there have been continuous related papers and research since the 1960s, and more than a team of people obtained Coenzyme q10 through chemical synthesis. However, until half a century later, the production of Coenzyme q10 by chemical synthesis still cannot be industrialized.

The semi-plant extraction and semi-chemical synthesis method also took about 30 years to mature. The key factor is to use 90% pure solanol as the raw material.

Now that we realize this, Yang Rui may be the only one in the world.

It can be said that in just one sentence, you can get a future industry worth billions of dollars.

Unfortunately, Yang Rui couldn't just say that.

If he uses an experiment or a paper to say it, he may receive high praise and affirmation from the biological world, but there is no need to think about money.

Japan, West Germany, the United States, France, the United Kingdom... There are too many super pharmaceutical companies, research teams that can use strong people and pure gold to create lawyers to throw Yang Rui out of the profit zone.

If you want to say that large pharmaceutical companies are the most despicable companies in the world, it is somewhat arbitrary, but if anyone says they are not despicable, they will definitely get a reverse lottery.

Even employees of pharmaceutical companies dare to say that our company does charity, but not that their company is charitable.

Therefore, Yang Rui must build a series of key technologies around core technologies, and then use a series of technologies to surround a series of key technologies.

For example, the synthesis of 90% pure lonyol requires a series of key technical support.

The advantage of this layer of barriers is that Yang Rui does not have to apply for patents for core technologies, or simply makes patented submarines, and only produces finished products and sells them in a strictly confidential manner.

This is also the magic weapon for small and medium-sized biotech companies to survive.

In the early 1980s, many biotechnology companies did not understand this point and thought that patents could protect themselves, but they were cheated by large pharmaceutical companies one by one.

In this year, the average lifespan of biotech companies in the United States was only 36 months. If there was another lawyer's fee, most medium-sized biotech companies with a capital of less than US$50 million would not be able to survive even 18 months.

With the level of a large pharmaceutical company, let alone delaying for 18 months, there are many lawsuits that they delay for more than 8 years.

This is also one of the reasons why Yang Rui is afraid to make medicines for the time being.

Western medicines have fixed names, usually a compound. Most of them are derivatives of compounds known in the pharmaceutical industry. It is not surprising that they are different from branched and side chains.

It is very simple to be copied for drugs like this. If you make money, it is almost natural to be copied.

Production technology is quite different. As long as you do well in confidentiality and a certain technological upgrade, it is no problem to maintain monopoly interests for several years.

A biotechnology company monopolizes the money it makes for several years, no matter how small the field is, it means a huge amount of capital.

Japanese pharmaceutical companies use semi-plant and semi-chemical synthesis in just five or six years. The accumulated funds are enough for them to completely develop the microbial fermentation method, and at the same time they can share the dividends.

Yang Rui has developed the technology of plant extraction and semi-chemical synthesis now, and he can earn more money.

Thinking of this, Yang Rui was also very motivated.

In just one weekend, several verification experiments were completed.

He had no intention of stopping, so he continued to find several journals and continue to conduct verification experiments. At the same time, Yang Rui also began to write the first review.

In the academic community, reviews can be regarded as a high-level popular science.

The review is a paper that the author re-sumes and organizes a large number of paper data, materials and opinions on a certain topic, and then analyzes and extracts it.

Simply put, Yang Rui only needs to summarize the article he has read recently, around a proposition, and even a review.

For example, "The Current Situation of Solanol" is an ordinary review article.

However, it is more difficult to publish such articles, and it is even more difficult to publish them in better journals.

In European and American countries, especially the United States and the United Kingdom, people who write reviews are often big names in the field, and they feel like giving lectures to ordinary researchers in an easy-to-understand way.

Of course, their motivation for writing reviews is usually not so pure. Most of the time, big bulls write reviews to make a quota of papers. Because many foreign schools also have the hard requirement of how many papers they have to write every year or every few years. Some big bulls write a review out of laziness or excellence and cannot complete the specified number, so they can write a review to get away with it.

Because it is a high-level popular science, there is no need to conduct in-depth research. After checking some information, you can usually write a summary in a few days.

Domestic reviews are often written by gentlemen who are far away from the big bulls. Some master's students who can't get a paper or want to get a SCI, some young lecturers who can't complete the task, or busy associate professors are all big readers who write reviews, and their levels are naturally uneven, so some departments simply list the reviews separately.

However, the Chinese academic community in the 1980s was not so particular. Due to its level, the review was still a very popular category. People who rely on it to get a title are like crucian carp.

Yang Rui didn't want to waste the search for so much information himself. In addition, the more papers there were, the better, so he started writing without hesitation.

Lu Zhi, who helped in the laboratory, saw that he was writing easily, wrote a large page of paper in one afternoon and couldn't help but ask: "What do you mean by writing a paper?"

"This is the first article, starting with a simple one." Yang Rui didn't write a paper slowly because a lot of information was in his mind. He had a clear understanding of the future development direction, so it was naturally easier to write a summary.

Seeing that he wrote all in English, Lu Zhi naturally knew that he was going to publish it abroad, so he couldn't help but ask: "Can you really publish it?"

Yang Rui said angrily: "You can't publish it, what will I do if I write it."

"It's normal that you can't write an article and publish it. Many seniors are working hard to correct it, and some will take several years to correct it." Lu Zhi was still a struggle-like person. If he was not struggling enough, he wouldn't even remember to publish an article abroad.

Yang Rui smiled disapprovingly: "I am different from them."

Now, even Yao Yue asked, "Where is different?"

"Talent." Yang Rui pointed to his head and said half-truely: "I have a lot of things in my head."

"You want to say that my head is empty." Lu Zhi was not proficient in experiments, and she didn't have many opportunities to get in touch with the instruments, let alone the unfamiliar instruments here in Yang Rui. In the past two days, her performance has not been as good as He Cheng of middle school students, and she has accumulated some emotions.

A silly girl like Lu Zhi immediately poured out her ideas and couldn't even save them.

Yang Rui laughed twice and silently agreed.

Lu Zhi was angry and grabbed Yao Yue and said, "We will leave and not let him do it anymore. Not only will we be tired, but we will also be scolded. We are simply capitalists. Whoever does it for you will be a puppy."

Yao Yue was in a dilemma, and Yang Rui said quietly: "I thank you for making braised pork at noon in the cafeteria."

Lu Zhi stopped unconsciously, and after a while, he called softly: "Wang!"

Yao Yue was so amazed that she said in shame: "Lu Zhi, you can't just move..."

"Just what?"

"Just call..." Yao Yue stomped her feet before saying everything.

Lu Zhi said indifferently: "What's this? When the educated youth order, if you make a pot of braised pork in the kitchen, everyone can queue up for a day. If you finish calling, there will be no braised pork, and everyone can rush forward and bit the captain to death in the kitchen."

The last sentence is obviously a threat to Yang Rui.

"Have you been an educated youth?" Yang Rui quickly changed the topic.

"I have been educated youth in the school. I went home and repeated the exam for a year before I passed the exam. Fortunately, I passed the exam, otherwise I would have to go to the coal mine. A classmate from the past went to the coal mine for two years to do ore treatment, but I couldn't sleep at night because of tinnitus. He said it was full of machine sounds." Lu Zhi complained and was mixed with gladness.

He Cheng, who was always doing experiments, suddenly said: "Last year, my second cousin sold his pigs at home, bought tobacco, alcohol and gifts, and arranged a temporary worker. He had to go down the well two years before he was transferred to a regular business. Their family ate vegetarian dumplings during the Spring Festival."

It is not as good as studying in a coal mine, but it is better to go to a coal mine than to be a farmer. This answer immediately silenced the two college girls.

Yang Rui didn't like this atmosphere, so he coughed and said, "Yao Yue, you can write a review, and show it to me next week."

"Me? I still can't understand some words..." Yao Yue was a little nervous. Now there is no search engine that can help translate English. Words you don't know must be found one by one. Only professional dictionaries can find out rare professional English, which has a huge workload.

Yang Rui shook his head: "I'm not asking you to write English. I'll write a Chinese article first. It won't be wasted anyway. It's just to accumulate some experience. After the paper is written, I'll help you edit it, and then teach you how to write a submission letter. The signature is your own."

Just like a big bull in later generations, Yang Rui simply disdains to leave a name in ordinary domestic journals, let alone a short review article like practicing writing.

Yao Yue relaxed for a moment, became nervous again, and whispered: "Can I write it out?"

"How can I know if I don't try it? Okay, go pack your luggage and go back after lunch. Yao Yue, if you have any questions, you have mail... mail me, write a letter, well, I have an experiment that you ask you to do, and I will also write to you to explain the experimental requirements and steps. If you have the results, mail the details back. Remember to memorize the English words and start reading English literature next month." In addition to email becoming mailing, Yang Rui's request was similar to that of his tutor when he was in the second year of his studies.

There are very few graduate students these days. Excellent undergraduates have to undertake the task of assisting with the experiment. Yang Rui now has an understanding of Yao Yue's experimental ability. As long as he does not assign tasks that exceed her ability, there will be no too many mistakes.

Lu Zhi silently recited the braised pork and went to the locker room lightly. Yao Yue left hesitantly, not only with nostalgia for the laboratory and people, but also with expectations for writing his own papers.

"If the classmates in the class knew that I had the opportunity to write a paper and publish it, they would be envious." Yao Yue's vanity also fermented slightly. She is a sophomore girl this year. If she had the opportunity to publish a paper, she might be a sensation at Hedong University this year.

......
Chapter completed!