Chapter 300 Application Project
"Yang Rui, show me your pipette." Tang Ji returned to the laboratory and remembered the words of light weapons and heavy weapons.
Yang Rui returned to the experimental state and said, "Xiao Sun, give your pipette to Professor Tang."
Sun Ruyue is one level higher than Yang Rui's sophomore year. At this time, she was called Xiao Sun, but she happily picked up the pipette.
Tang Ji took the pipette and looked at it carefully, and asked for a moment: "How much does this pipette cost?"
"$600." Sun Ruyue rushed to say: "Foreign imported."
"See it." Tang Ji glared at Sun Ruyue with annoyance and asked, "Yang Rui, did you buy it yourself?"
"It was bought by Jielikan."
"It doesn't matter if you get it to our laboratory for use?"
"I will definitely take it back later, and it's nothing to use it for the time being." Yang Rui was not prepared to provide instruments and equipment to Tang Ji Laboratory. No matter what, Tang Ji Laboratory is also qualified to be selected as a national key laboratory. With a fund of millions a year, it's nothing to buy a few US$600 pipettes, it's just a question he wants or not.
Yang Rui bought imported pipettes at high prices, on the one hand, it was due to years of accumulation of resentment, and on the other hand, it was the requirement of PCR experiments. Of course, the most important thing was that he was well-funded.
Tang Ji did not have such a strong demand, so after trying the pipette a few times, he sighed and said, "It's great, it's expensive."
Sun Ruyue said disappointedly: "We can't buy it."
"There are 9 people in our laboratory, and it will cost $5,400 to buy 9 pipettes? If the evaluation team sees us spending money like this, they have to speak." Tang Ji shook his head and said, "The electrophoresis laboratory cannot use such good equipment at present. Yang Rui can use his own. You should use the original equipment in the laboratory."
This time, even Wang Ying made a tragic cry. It is very painful to use bad instruments after using them well. The corresponding comparison can be new computers and old computers, smart phones and simulators, and most of the fun will be spent.
However, scientific research dogs have no say. Tang insists on this point, and any wailing is useless.
"From tomorrow, I will leave a pipette." Yang Rui understood what Tang Ji said.
Tang Ji touched his head embarrassedly and said, "It's not that you don't want to use it, but you're afraid that the evaluation team will pick on it. After this period of time, it's going to be fine. OK, just do your own thing."
After dispersing the people, Tang Ji talked about potassium channel protein with Yang Rui and said: "It must be admitted that I did not pay attention to your recent experiments before, because you have published a paper. I thought, it will take two or three months to publish your second paper, but I didn't expect it to be so fast."
"The experiment went smoothly, and I didn't finish it all, so I published the paper first." Yang Rui would publish the paper as long as there were phased results. This is actually a relatively normal practice. Unless it is a special method, such as the PCR paper has a unique conception and a simple method, most laboratories will publish phased results papers. For example, China's artificial insulin research, although it was in the 1960s, the papers were still published abroad, and more than 20 articles were published one after another, which is not easy.
"I see that your paper contains the words "Peking University Electrophoresis Laboratory" on your paper, which is quite good. Let Sun Ruyue follow you and help you, and you will teach him experimental methods and some professional knowledge." Tang Ji gave Yang Rui the youngest scientific research dog.
Yang Rui published his paper in the name of the electrophoresis laboratory. Although the first author is Yang Rui, both Peking University and the electrophoresis laboratory will undoubtedly benefit from it, which means that the number of papers under its jurisdiction is increasing. Although one or two ordinary papers are insignificant for institutions like Peking University, it is good to have one more paper for electrophoresis laboratories that are competing for key laboratories across the country.
Yang Rui thanked him without hesitation. He really needs an experimental assistant now and cannot even wash the bottle by himself. That would be a waste of time. Although Sun Ruyue had the help before, it was not justified after all.
"If you have any help in the next research, you will come to me." Tang Ji clapped his hands and said, "I said I would help you apply for school funds before. In this way, I will fill out an application form for you tomorrow. You can also prepare it to see if it can be done as a topic. If you apply, it will be at least a thousand yuan, what do you think."
"That's great." Yang Rui entered Tang Ji's laboratory, in addition to seeking privileges, to obtain funds, reputation and corresponding convenience.
Before this, Yang Rui's funds were all paid by himself, and the external name was sponsored by Jielikang or Huarui Company. As a patent project or a profitable pharmaceutical project, there was no problem with this method, but in the university laboratory, Yang Rui was doing basic projects, so it was a bit unfair to spend his own money.
In the pharmaceutical industry, a new drug usually goes through at least three steps. First, some scholars have completed a basic study, such as potassium channels that can affect heart arrhythmia. After learning about this study, researchers from biotechnology companies will conduct the second step based on this study to develop or discover a potassium channel blocker to treat heart rate disorders. This blocker can be a brand new synthetic compound or an existing compound. Finally, the third step is to extract or produce this existing compound and perform standard tests specified by various institutions.
The third step of producing coenzyme q10 by Yang Rui was the plant extraction method. The second step before Coenzyme q10 was completed in the early 1970s, and the first basic research was completed in the 1950s.
It means that it takes 30 years for the drug Coenzyme q10 to face consumers.
Among these three steps, the third step is the key to profitability and is also the most concentrated part of pharmaceutical companies. The second step is already difficult to apply for a patent, so only large pharmaceutical companies are involved, hoping to take the lead in this.
Most of the research conducted in university laboratories is basic, that is, the first step is that they spend a lot of money and do not necessarily know what they will do. Therefore, except for even super pharmaceutical companies, they often only provide funding, rather than direct investment. Moreover, because it is purely basic research, there is no patent scientific research. You cannot apply for patents for cell potassium ion channels, just as scientists cannot apply for patents for newly discovered glaciers or organisms.
However, the qualifying of the first, second and third steps is exactly the opposite of making a profit. The third step that is easiest to make a profit is the lowest, and the first step that is difficult to make a profit is the highest.
In terms of difficulty, it can be said that the production of drugs for treating cancer is the easiest, and what to use to produce cancer drugs is the most difficult part.
Most of the honors, such as the Nobel Prize, are awarded to researchers in the first or second step, and few are given to the third step.
The current funding of domestic laboratories is not much, but as far as the country is concerned, there are actually quite a lot of them, especially the accumulated instruments and talents, which will only increase, as well as the benefits of venues, names, etc., and there are many conveniences.
The next day, Yang Rui sorted out his resume and wrote about various elements such as the project application goals. He then submitted the funding application under the guidance of Tang Jiji.
Because it is an application for funding in the school and the staff in charge of accepting the school office, after reading Yang Rui's application form, he put it in a special kraft paper bag and said: "The school is currently short of funds and does not provide much funding for students. You must be mentally prepared."
"It's enough to have thousands of dollars." Yang Rui's potassium ion-related experiments are definitely not enough. However, he is currently using the instruments of Tang Ji's laboratory, and his expenses are mainly consumables, which are more or less supplements.
However, the office staff laughed softly and said, "It's better to think less. If you apply, someone will notify you."
"Okay." Yang Rui's psychological expectations were instantly lowered.
Tang Ji comforted him: "This is your first time applying for a project, so it's good that you can approve it. As long as you have the results and pass the acceptance, the next application will be easier. Besides, you can also apply for projects from Beijing and the country, which are the big part of the funding."
"I understand." Yang Rui recalled his graduate school years and worked with his supervisor to run projects, thinking: Although it is different, the essence is indeed the same.
Chapter completed!