Wei Zhenxue still thinks that girls in the biology department are very good.

Not only Wang Xiaoyun and Grace feed rats and mice lovingly every day, but Tan Min, the experimental assistant recruited in the later stage, also worked hard and carefully cared for them.

If Wei Zhenxue had a richer vocabulary, he would definitely use "love" to describe the scene here.

In addition, Grace also persuaded Yang Rui to order a batch of pigeons and suitable pigeon cages and keep them in the next yard. The two small courtyards were separated from each other and formed a corner of the breeding courtyard.

However, Yang Rui rarely goes to the yard where rats, mice and pigeons are raised. When he arrives at his position, he usually only needs to make a plan. Yang Rui can choose the work he wants to do and refuse the work he doesn't want to do. This is also one of the advantages of having his own laboratory.

However, although he rarely goes to a breeding home, Yang Rui still established the 3R principle in the form of a system, as the guiding direction for Huarui Laboratory's first animal experiment and subsequent animal experiments.

In addition, Yang Rui also wrote the 3R principle into a slogan and painted it on the wall of the breeding home. Even every lock of the breeding home was painted with 3R yellow font.

The so-called 3R is the abbreviation of Reduction, Replacement and Refinement. Reduction refers to the use of fewer animals in scientific research to obtain the same or more experimental data. In general, the amount of animals used should be the minimum number that can achieve the experimental purpose, and it cannot be used more than the minimum number of animals that can obtain meaningful experimental results based on reasons such as saving time or personal convenience.

The requirements for substitution and optimization are higher. The former requires other methods to be used as much as possible instead of animal experiments, while the latter improves and improves experimental procedures to reduce and reduce pain and damage caused by experimental animals. In short, it is to improve animal welfare.

This is a theory that has been in 1959, but it was not until the 1970s that the world's major developed countries gradually became popular, and third-world countries such as China have not yet been widely involved.

Although there are also researchers who oppose the 3R principle, Yang Rui himself is not listed here, and he is willing to support the moral status of animals under the conditions within his ability.

As the laboratory boss, Yang Rui decided on the animal principle of 3R, which Wei Zhenxue, Huang Mao and Li Wenqiang and others must implement.

There is actually no need to object. The 3R principle is only to reduce animal damage during animal experiments, not to interfere with the experiments.

Of course, in order to use mice at the minimum number, all participants in the experiment must make careful and reasonable preparations before the experiment, analyze the experimental data, and do more statistical analysis to determine that there will be no statistical differences in this number of experiments.

This is naturally more laborious and takes more time than ordinary experiments, but Yang Rui believes it is still worth it. As a biologist, Yang Rui supports the moral status of animals, that is, a life is sentient, so it has a moral status.

Compared with Wei Zhenxue, Huang Mao and others' compliance and focusing on reduction, Grace further improved to optimize.

In order to meet the living habits of guinea pigs and rats, she changed the feeding time to night. She strictly regulated the lighting control of the breeding house and required the keepers not to turn on the lights without authorization even at night, so as not to affect the lives of rats and mice.

The living spaces of the guinea pigs and the guinea pigs have also been changed because of Grace. Under her insistence, the workload of the guinea pigs at least doubled.

But in fact, it is just a few dozen yuan more a month and a little more hiring one more scientific researcher.

After a few days of balance, Yang Rui's assistant Comrade Wei Zhenxue, under the guidance of Grace, selected 55 gussets, big white rats and 11 pigeons, and under the guidance of Grace, and underwent a simple physical examination, such as weight measurement, and then began to add iron through food.

In a few days, the rats, rats and pigeons who were dyed with iron through oral dyes entered a state of iron poisoning.

Grace explained to Yang Rui and immediately started grouping and taking medicine, which was equivalent to depriving Fan Lunding of his only work value.

As an assistant, Wei Zhenxue naturally had to actively participate, but he was not very adaptable to mice, so he came to the breeding house and asked: "Can I be responsible for pigeons?"

Grace and Wang Xiaoyun's eyes were a little strange.

Wang Xiaoyun asked: "Are you sure someone is responsible for the pigeon?"

"I know that the number of pigeons is relatively small, but the number of pigeons is relatively large is not. I will feed the pigeons. You two and Tan Min feed the mice. On average, the number is similar, right?" Wei Zhenxue still understands the truth when he occasionally doesn't make any mistakes.

"Tan Min wants to feed the healthy guinea pigs over there, but if you are willing to be responsible for the pigeons alone, we two are responsible for the guinea pigs and the rats." Wang Xiaoyun said humbly.

"Really? Don't worry, I will definitely feed the pigeons."

"It's the responsibility of the pigeon."

"Yes, yes, yes, it's the pigeon." Wei Zhenxue smiled loudly.

Several people distributed evenly, and under the guidance of Grace, they began to feed oral deferrosterone made of different active substances and made detailed records.

Oral agents are fed according to body weight. Mice, rat and pigeon can basically obtain similar feeding doses.

All these experimental animals were also mentioned in auxiliary laboratories, allowing other researchers, including Yang Rui, to observe the specific situation.

The purpose of the entire animal experiment is to observe whether there are serious drug reactions, such as severe allergies, teratogenic or even death. The drugs made of this active substance are basically eliminated.

At least 20% of the new drugs were suspended during the animal experiment stage.

Drugs that cannot pass animal experiments are definitely not allowed to be taken by humans, which means that this drug is not qualified for clinical testing at all. There are actually problems here. For example, for the same allergic reaction, animals and humans may get different. Therefore, drugs that are allergic to animals may not be allergic to humans.

However, few pharmaceutical companies will analyze problems like this. Some pharmaceutical chemists are even too lazy to screen for the causes of allergies. This is because judicial litigation in Europe and the United States is too active. If there is a problem with animal experiments and they insist on conducting clinical trials, the amount of compensation will make any pharmaceutical company more powerful.

Under the system of jurors and punitive fines, some pharmaceutical companies will receive huge fines even if they do nothing wrong. Therefore, raising corporate standards is a wise choice for a century-old company.

Although under this social situation, some drugs that could treat important diseases were rejected, European and American countries still stubbornly adhered to their drug review system.

In contrast, it is much easier for Chinese pharmaceutical companies to survive. At least things like Chinese patent medicines can still easily enter hospitals and pharmacies and create a lot of profits.

However, the cost of modern pharmaceutical development is not something that the Chinese market can afford. Only when deferrosterone is listed abroad can it be possible to recover its principal.

If you want to sell the patent for deferrosterone, you must naturally show your expectations of profit.

Even Grace understands the logical relationship. She doesn't care about money, but she knows the importance of funds in the pharmaceutical industry.

If there is really an infinite amount of capital invested in pharmaceutical companies, although it cannot make humans live forever without diseases, it is likely to be able to solve the disease and pain of 90% of the world's people and extend the average life span of 90% of modern people within decades.

Unfortunately, there is not so much evil money in the world.

Grace therefore cherishes Huarui, a company that is willing to spend money on rare diseases. When the animal experiment started, Grace left the hotel room and lived in the guest room of Huarui Laboratory. Every day, she observed, cared for and recorded the experimental process.

One week later, two active substances developed drug allergies and liver dysfunction, and were forced to withdraw from screening.

Then, the pigeons in charge of Wei Zhenxue also began to have adverse reactions - vomiting.

Seeing a large amount of vomit appearing in the pigeon cage, Wei Zhenxue was about to cry without tears. While cleaning, he complained: "Why did the pigeons who were responsible for vomit? So many of you mice are all well."

"Because the teenage mice won't vomit." Wang Xiaoyun was very innocent.

Wei Zhenxue, a major in chemistry, was a little confused: "What does it mean to not vomit?"

"There is a diaphragm between the two stomachs of the mouse. This diaphragm muscle cannot hiccup or vomit. Therefore, the mouse will not vomit." Wang Xiaoyun explained seriously.

"There are really animals that won't vomit?" Wei Zhenxue didn't believe it.

"Mushs, rabbits, horses, and Guinea pigs will not vomit, so they are easily poisoned, and the vomiting reaction of guinea pigs is not sensitive." Wang Xiaoyun paused for a moment, continued as if giving a lecture: "The vomiting reaction of pigeons, domestic dogs, monkeys and cats is sensitive, so it is suitable for vomiting experiments."

Wei Zhenxue was stunned for a moment, slowly turned around, looked at the messy pigeon cage, and hesitated: "What do you mean..."

"For drugs, vomiting reaction is a must-test item, so each active substance must ultimately determine whether it will cause vomiting reaction." Wang Xiaoyun patted Wei Zhenxue's shoulder and said, "Please be responsible for the pigeon."
Chapter completed!