The number of candidate compounds is reduced day by day.

From the first more than thirty species to more than twenty species, to more than ten, until 13 compounds are left, the reduction rate is not reduced.

The compounds that were eliminated in the early stage mainly had serious reactions in animal experiments. The rules for applying for new drugs in various countries are actually similar. Anyone who has serious reactions in animal experiments is not allowed to enter clinical trials, which means that a compound has been eliminated.

This is a veto, but from the perspective of pharmaceutical companies, it is the easiest part.

Because the compounds that have been rejected will not incur additional costs.

On the contrary, the remaining 13 compounds have to be continuously incurred during further animal experiments.

It is most appropriate to describe this process by spending money like flowing water.

Batches of mice, rats and pigeons were stained with iron orally, and then candidate compounds were taken separately, and then various tests were performed.

The cost of various chemical agents and instruments alone exceeds 10,000 yuan per day.

Huang Mao and others did not personally participate in the drug group research, but they were also frightened when they watched from the side.

Seeing that it took them a week to reduce the candidate compounds from 13 to 12, Huang Mao couldn't help asking: "Will an animal experiment take one year for this progress?"

Because Grace is in, Huang Mao used English, and the former immediately replied: "It is normal to do animal experiments for a year."

Huang Maomo calculated that the average research cost of more than 10,000 yuan per day, how much is the cost of doing animal experiments for one year? It is definitely more than 4 million yuan!

Although I have known that developing new drugs costs a long time ago, the feeling of money flowing away from me is even stronger.

Huang Mao couldn't help but say, "We Huarui have always exceeded the average speed in our experiments, so you can't really do it for a year."

Grace thought about it with her head, then straightened her body and stretched her body, and said, "Internationally, there are an average of ten medicinal chemists in the laboratory that develops new drugs, and two to three biologists are involved... We have it now, I will calculate it. I am a medicinal chemist, Yang Rui and Wang Xiaoyun, so, you are right, we can't really do it for one year, but it's even more likely to do it for five years."

Huang Mao’s desire to complain could fill the entire laboratory: “Are you not in a hurry?”

After a long time, Huang Mao said this.

"What does it have to do with me if I can't afford a drug chemist in the laboratory?"

"Wait for five years, wouldn't you also waste five years?" Huang Mao didn't understand even more.

"No, from now on, five years later, there may not be any other pharmaceutical companies that will do ferrosterone. Moreover, since we have started animal experiments, we must complete them. Otherwise, we will be irresponsible to other pharmaceutical companies and irresponsible to patients with thalassemia." Grace's thinking circuit is very strange.

Huang Mao didn't react for a long time and asked, "Why?"

"You are asking..."

“The irresponsible part.”

"Gris means that if we stop halfway through the animal experiment, other pharmaceutical companies may think that our animal experiments are incredibly bad situations, so they completely gave up the deferrotonide project." Yang Rui listened to their conversation and interrupted, saying: "We are in good condition at present. No pharmaceutical company will give up the project at this stage. Therefore, unless we encounter other force majeure, the animal experiment will definitely be completed. If it is not completed, other companies and even the FDA will consider this situation. In case of a lawsuit, lawyers will definitely ask the bottom line."

Huang Mao understood, and this time he changed to Chinese and asked: "Is it good to complete it?"

"The projects that have passed the animal experiment can be sold at a good price."

“How to sell?”

"There is a special market." Yang Rui was actually not very clear. He had the opportunity to play games such as mergers and acquisitions before.

Huang Mao opened his eyes wide and asked, "Is it expensive?"

"It won't be too cheap, just this is the expense." Yang Rui curled his lips.

Huang Mao also instantly realized that the experiment conducted by Huarui Laboratory in a relatively cheap way would cost RMB 20 million in five years. If a foreign company hires 10 medicinal chemists and two or three biologists, the salary of a year would have to be paid millions of dollars, not to mention other costs.

"It's just that it's too long." If you make tens of millions of yuan in five years, Huang Mao doesn't think there is a high income. There are too many factories with annual profits of one million or tens of millions in China. Huarui Laboratory's annual expenses are now more than one million US dollars, especially in the ongoing PCR lawsuits. American lawyers charge a lot of fees, and 20 million yuan is not enough to fill the hole.

Thinking about it this way, when it was lunch time, Huang Mao sat down next to Yang Rui, smiled at Grace at the same table, and said in Chinese: "Yang Rui, otherwise, don't spend all your time on deferrosterone."

"Why?" Yang Rui asked strangely.

"Five years!" Huang Mao sighed and said, "Yang Rui, don't blame me for being ugly. Don't look at your high efficiency in doing things now and have good grades. You think you will be like this in the future. It's impossible. You are 20 years old this year, which is the age to achieve the best results. Why does our country want to run a junior class? It is to let scientific researchers have a longer scientific research life and start research at the age of 20. Like you, the high yield period can last until 30 years old, 35 years old, and even more powerful, it can last until 40 years old. In these 20 years, it will be twice as long as ordinary scientific researchers."

After a moment of pause, Huang Mao said again: "Think about it, you'd better take five years to do ferrosterone for 20 years in scientific research? I'm not saying that ferrosterone is not important, but in the current animal experiments, I can do it, Lao Tu can do it, and Wang Xiaoyun can do it, why do you waste your golden time on this? How many things can you do in five years?"

Yang Rui was stunned by Huang Mao.

In his drug group, there are only Wang Xiaoyun, Wei Zhenxue and Grace who volunteered. In fact, because animal experiments are relatively simple, he is unwilling to waste the time of the calves that he finally brought.

People like Huang Mao, Li Wenqiang, etc. are all those who are capable of publishing CELL-level articles in the future, so why should they be used for simple physical work?

However, Yang Rui forgot how much time he has spent on it.

After careful calculation, the entire animal experiment lasted only two weeks, but for a scientific researcher, it took a lot of time.

"Just treat it as a vacation and change your mind." Yang Rui smiled and explained to himself and Huang Mao at the same time.

Huang Mao was silenced.

Wei Zhenxue, who was sitting not far from this table, was just pricking his ears and eavesdropping - only he could do such a thing - and coughed at this time and said, "People are different. Some people take vacations to go out to play, some people take vacations to go home to sleep, and some people take vacations to pull the spine of the mouse..."

"I didn't even move a little mouse." Yang Rui explained again.

"I was wrong. Someone liked to watch people pull the spine of a mouse on vacation." Wei Zhenxue laughed and said it perfectly.

Yang Rui was speechless and suddenly felt that he had a perverted tendency. Instead, Yang Rui thought again, and he thought that it was not a big deal to be perverted or not.

"I'll take another week off. If there is no effect, I'll consider changing." Yang Rui said as he stood up, patted Wei Zhenxue's neck twice, and then stopped moving.

Wei Zhenxue only felt goosebumps all over his body, and the warm back of his neck made people feel cold.

Yang Rui pointed his thumb on Wei Zhenxue's neck bone, thinking about how to speed up the progress of animal experiments.

As a simple arrangement and combination elimination experiment, the speed of the animal experiment can often only be changed according to the amount of resources. The space for technology to be used is very small, because no matter how good the technology is, you cannot see the changes of a compound in the human or animal body.

If you don’t try it, who knows how effective the compound is, whether it will metabolize or enrich it, whether the metabolic pathway is as expected, and whether the metabolic products are beyond imagination...

Yang Rui knows.
Chapter completed!