More than 30 compounds used in animal experiments were synthesized step by step by step by Yang Rui.

Naturally, Yang Rui also knew the outcome of these compounds very clearly.

In the final analysis, Yang Rui only needs one or two compounds in the end, at most no more than four compounds, and the remaining compounds must be eliminated.

If you want to speed up, the best way is to get the compounds that should be eliminated as soon as possible.

The reason why active substances are screening is getting slower and slower is naturally because the remaining compounds are getting safer. Those obviously unsafe compounds, such as those with acute toxicity, have been brushed out in several early tests.

But in the next test, those unsafe compounds will eventually be eliminated, it is only a matter of time.

The problem is that Yang Rui doesn't want to wait that long.

Some tests will take a long time to go, and some will not even be needed in the 1980s, but will only be needed in the 1990s.

But as a new drug developer, it is so normal to consider the situation ten years later. In ten years, new drugs may not be available for the market. Even the drugs that are launched may be withdrawn.

For example, a large number of drugs withdrawn in the 1990s were metabolized by mixed functional oxidases, which is not a problem in itself. However, patients often do not take one medicine, but use multiple medicines in combination. The result is that these drugs metabolized by mixed functional oxidases are very likely to undergo cross-reactions. Such consequences are either not tested in animal experiments or are the final tests.

Because drug cross-reaction is not a key consideration in animal experiments.

But from the perspective of whether a drug is successful or not, cross-reaction of drugs cannot be eliminated.

Similarly, there are genotoxicity issues, metabolites issues, pharmacokinetic characteristics, and even whether the raw materials are easy to obtain and whether the synthesis cost is reasonable and cheap.

These problems are not considered by ordinary people, but pharmaceutical companies must consider. For example, cold medicines in 10 years will definitely not consider products that are used as raw materials. Some raw materials that are subject to strict monitoring have such problems.

If you think about it, you can understand that if you buy a box of cold medicine, you need to check your ID card and limit the quantity. The sales volume can be imagined. In European and American countries, it is equivalent to turning over-the-counter drugs into prescription drugs. In order to achieve several times the sales poor, pharmaceutical companies must be careful.

In short, all the work of pharmaceutical companies is done with caution.

Whether a drug can become a clinical candidate compound after the animal experiment is completed means that for pharmaceutical companies, it will cost US$20 million to US$200 million, and wait for four or five years to conduct clinical research.

Such an amount and time are enough for the two countries to engage in a local low-intensity war, so how can pharmaceutical companies be careless and cautious?

What Yang Rui needs to do is to eliminate the compounds destined to be eliminated as soon as possible. Only in this way can he focus his time and energy on a few compounds and then make detailed tests and analysis.

In the end, if these few compounds can meet the requirements of clinical candidate compounds, even if Yang Rui cannot personally promote them to go to the market, some pharmaceutical companies will actively do it.

The only troublesome thing is that such elimination work requires Yang Rui to spend more time participating, not the other way around.

This naturally takes some precious time.

However, Yang Rui also felt that he needed such an experience. Deferrotonide was something he wanted to do, not the medicine he needed. But one day, if Huarui Laboratory wants to grow and grow, it still needs to make the medicine by itself. By that time, Yang Rui hopes that he is a manager with pharmaceutical experience, not a rookie layman with great ambitions and talent.

Yang Rui occupied two compartments in the main laboratory and began the design work of animal experiments.

It is still the part where Wei Zhenxue and Wang Xiaoyun are responsible for animal experiments. Yang Rui only makes requirements and looks at the experimental results, and does not directly participate.

After all, animal experiments are not a good time. Even if the 3R principle is adopted, some experiments are still uncomfortable.

As a graduate student in the Department of Biology, Yang Rui has more than 100 rats under his command, but this does not mean that he likes this job.

On the other hand, Yang Rui doesn't need to do it personally by feeding compounds, observing and calculating the results, and ultimately killing animals.

Yang Rui is already busy with design experiments.

In order to pass the FDA or a possible European country's Drug Administration, Yang Rui first had to make detailed experimental records, including preface and follow-up questions, that is, what they thought, how they did, and what they were like.

To be more specific, is why you think this way, why you do this, what you use to do, and the meaning of the results you make.

This complex process can protect the public to the greatest extent and also restrict scientific research progress to the greatest extent.

However, although Yang Rui was very busy, his progress caught Wei Zhenxue and Wang Xiaoyun off guard.

In just two days, the two couldn't bear it anymore. When Yang Rui checked, he found that they had not completed one-third of the task.

"The reaction time of the guinea pig is not decided by us." Wang Xiaoyun explained helplessly, and was still busy writing experimental reports. They wanted to write more things than Yang Rui.

Wei Zhenxue was so tired that he couldn't even turn his head, and said, "I haven't been asleep all day and night. Boss, please add an assistant."

Yang Rui, who worked for 110 hours, was shocked when he saw Wei Zhenxue like this and asked Wang Xiaoyun: "You really haven't slept all day and night?"

"I went to bed yesterday, Lao Tu helped me a little." Wang Xiaoyun felt a little embarrassed.

"Where is Grace?"

Wang Xiaoyun hesitated for a moment and said, "She said she would not accept your order."

"Why?"

"That's probably what it means." Wang Xiaoyun said: "Gris is continuing to follow the regular steps little by little."

Yang Rui pondered and asked: "What about you, do you think my experimental design is correct?"

"We have sieved out a compound. Judging from the results, the experimental design can be used." Wang Xiaoyun didn't need to praise Yang Rui, and she said it was very realistic.

Yang Rui nodded slightly and said, "Then continue to be in the current state... Isn't it okay to not add people?"

"You must add people, at least the instruments are stopped, so that you can speed up the screening."

This sentence touched Yang Rui. The instruments in the laboratory are limited, but it is still feasible to use them in a different way.

"I'll help you find two more people." Yang Rui was unwilling to increase the laboratories too quickly. The cost of paying is on the one hand, and limited resources are on the other hand, and the busyness of the laboratories in Huarui Laboratory is also second to none.

After some preparation, the amount of compounds decreased rapidly.

The cross-reaction of drugs that are not usually done, three compounds were screened out in one breath. If this method was not used, these three compounds might take hundreds of hours for the experimenter and tens of thousands of yuan to be eliminated.

In a few days, the number of alternative compounds dropped to an astonishing 8 types, and Grace couldn't help but come to seek the scriptures.
Chapter completed!