It is not only Grace who is paying attention to the scientific research progress of Huarui Laboratory, but also Jielikon, as well as pharmaceutical companies from Japan and Norway.

After discovering that the number of alternative compounds in Huarui Laboratory dropped rapidly, several companies simultaneously investigated the situation.

The 8 alternative compounds are considered an important node. If they drop rapidly due to technical reasons such as safety, it means that this compound may not be able to pass animal experiments, but if it is the opposite, it means that this compound has a lot of room for selection.

Abundant choice space means a cost that may be greatly reduced.

Yang Rui made more than 30 compounds in one breath, and the synthetic lines he adopted were naturally strange. Some lines were simply unimaginable with normal thinking.

Nevertheless, most of the more than 30 compounds use expensive raw materials or catalysts.

It’s not that expensive raw materials or catalysts cannot be used in drugs. The key to the problem lies in profits.

These companies focus on the catalyst formula of Coenzyme Q10 for profit, while the same is about deferrosterone.

Moreover, compared with the catalyst formula of Coenzyme Q10, the level of deferrosterone is much higher.

A new drug is also a core project for a super-large company like Pfizer every year, while for ordinary medium and large pharmaceutical companies, it often represents a fraction of the company's assets.

In short, if a pharmaceutical company can produce a new drug, it will be ranked among the world's pharmaceutical companies.

Although there are tens of thousands or even more pharmaceutical companies around the world, 99% of which are generic pharmaceutical companies.

Generic drug companies are not necessarily weak, but original drug companies must be strong. Whether it is strength, laboratory, or spirit, they are powerful, because the powerful strength, laboratory and spirit brought by a new drug may be converted into money in the future.

The dozens of new drugs that appear around the world every year, half plus half and more than half, are all from multinational pharmaceutical companies.

There may not be one remaining belonging to small and medium-sized pharmaceutical companies a year.

This is a risky business.

However, there are still people who are constantly involved.

Jellicon is a multinational pharmaceutical company with annual sales exceeding 10 billion US dollars. However, the number of new drugs they can increase each year is also limited, usually hovering around three types.

Deferroster may not be a bombshell, but who knows?

Many drugs were developed after they were launched, and then they became bombs that sold 10 billion yuan.

Therefore, those who were originally staring at the Coenzyme Q10 catalyst inevitably targeted the animal experiments that were very smooth.

However, Yang Rui did not agree to visit companies such as Jielikang, nor did he agree to visit companies such as Japan and Norwegian.

He didn't even let Grace know about his detailed experiment process, only the briefing came out of the small compartment and appeared before others in the morning report.

So, in the next two days, Yang Rui removed a compound again and then ended his independent work in the laboratory.

The remaining seven compounds do not have much risk. In fact, they all may be used as finished drugs for deferrosterone, and several of them appear as generic drugs, so naturally there is no major safety problem.

Yang Rui just needs to follow the steps and let them complete the animal experiment.

And the closer we get to completion, the more curious companies such as Jelikon are.

At this stage, they were really just curious.

However, this curiosity also made them feel itchy.

On the third day after Yang Rui screened out the last seven compounds, Franky directly brought a group of people to Peking University.

As the saying goes, monks can't run away, but when they find Peking University, Yang Rui really can't run away.

Not only can you not escape, but you can't be as good as being low-key.

A group of foreigners have arrived at school, so everyone must pay attention to it.

When Yang Rui received the call outside to pick up someone, Dean Liu also ran out.

"Oh, so many international friends come to our school to visit, why don't you say that Yang Rui? What's the purpose of this time?" Dean Liu said something like a complaint, his eyes bright like a monkey.

"For the study of deferrotonin in Huarui Laboratory." Yang Rui explained in one sentence.

Dean Liu naturally knew about this, and said with a "oh" voice: "It's all for this medicine. Didn't you say you don't make money?"

"It won't make a profit in the short term, but it won't be certain in the long term." Yang Rui continued: "No matter how you say it is, it's all an original drug. If you add an original drug, you will have many benefits."

"It means that you smelled the fishy shark again?" Dean Liu nodded in understanding.

Yang Rui smiled: "It's not that serious, it's the stage of animal experiments. Even if they take it, they can't make money."

There are thousands of drugs that pass animal experiments every year, but only a few are valuable.

"What are you doing?" Dean Liu's attitude became very fast.

"I still smelled fishy, ​​but I didn't see the meat. I guess I won't rob it too fiercely."

Yang Rui turned around and took Dean Liu to entertain representatives of foreign companies who came from afar.

The canteen director also went there, and asked along the way: "Do you want to open a private room? What should we give them food?"

"Just eat the documents." Yang Rui answered neatly. When he arrived at the place, he really fed a group of people and a bunch of documents.

Arnold and others were happy and quickly looked through it. Grace was the first to grab it and said, "It's too thin."

"After you go back to the laboratory, I will give you a thickened version." Yang Rui smiled and comforted her. After all, he took the initiative to work for nothing, so he should give some privileges.

Grace seemed quite satisfied, but her expression changed very weakly, so she just went to read the information.

Arnold muttered something beside him, comparing the completion of various aspects of animal experiments one by one.

Clinical candidate compounds have some iconic characteristics. The more these characteristics are, the more necessary it is to conduct clinical trials.

Jielikon is a multinational company that often engages in mergers and acquisitions. It has its own method. By rating these characteristics, it can judge the approximate value of a compound.

Franky helped Arnold quietly calculate, saying: "The animal model is effective, there is no genotoxicity, no acute and chronic toxicity. You can get the basic 15 points."

"The target of action has been verified clinically. Iron chelating agent is very simple, it is counted as 3 points. There is a competitive advantage, but can it be better than iron amine?"

"It's better to count 2 points, a total of five points."

"This will be 20 points. For raw materials and costs, these compounds are different... I see, I can basically get five points. 25 points?" Arnold took a breath.

Jielikan's calculation formulas are simple and complex, but they have never used 60 points as the standard. The oral calculation formulas they use now can reach 30 points, which is a rare high score. Companies usually contact and try to acquire them.

French looked down at the document and said, "The seven reserve compounds should be given at least 10 points, right?"

"Well...their animal experiments have not been completed yet. I don't think I'll forget about this item of reserve compounds. Who knows how many types can pass in the end?" Arnold didn't want to give a high score of 35 points.

Frankie said indifferently: "Because it is a drug for rare diseases, it has a 7-year drug sale period. Do you want to add points?"

Arnold hesitated for a moment and said, "Although this is the case, rare disease means low sales. If the sales are to make up for the shortfall in sales... let's count 3 points."

Although it was just a private estimate, he felt embarrassed to be too unfair.

Frankie said: "That's 28 points?"
Chapter completed!